3943-95-1Relevant articles and documents
Tripterine (iso) ferulic acid ester derivative as well as preparation method and application thereof
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Paragraph 0147; 0148; 0149; 0150, (2019/05/08)
The invention discloses a tripterine (iso) ferulic acid ester derivative as well as a preparation method and application thereof and belongs to the field of biological medicines. The tripterine (iso)ferulic acid ester derivative is of a structure with a formula I as shown in the specification; in the formula, R1-R6 are respectively selected from H, alkyl, heteroatom-containing alkyl, halogen or nitryl; X is selected from saturated or unsaturated direct-chain aliphatic hydrocarbon segments with 2-5 carbon atoms. The preparation method of the compound is gentle in reaction condition, low in reagent toxicity, easy in raw material obtaining, convenient in aftertreatment and high in yield. Pharmacology experiment shows that the compound disclosed by the invention has excellent anti-tumor activity and can be applied to preparation of anti-tumor medicines.
Palladium nanoparticles immobilized on amphiphilic and hyperbranched polymer-functionalized magnetic nanoparticles: An efficient semi-heterogeneous catalyst for Heck reaction
Tabatabaei Rezaei, Seyed Jamal,Shamseddin, Azin,Ramazani, Ali,Mashhadi Malekzadeh, Asemeh,Azimzadeh Asiabi, Pegah
, (2017/09/01)
To address the obstacles facing the use of palladium-based homogeneous and heterogeneous catalysts in C─C cross-coupling reactions, a novel semi-heterogeneous support was developed based on hyperbranched poly(ethylene glycol)-block-poly(citric acid)-functionalized Fe3O4 magnetic nanoparticles (Fe3O4@PCA-b-PEG). Because of the surface modification of the Fe3O4 nanoparticles with amphiphilic and hyperbranched polymers (PCA-b-PEG), these hybrid materials are not only soluble in a wide range of solvents (e.g. water, ethanol and dimethylformamide) but also are able to trap Pd2+ ions via complex formation of free carboxyl groups of the PCA dendrimer with metal ions. The reduction of trapped palladium ions in the dendritic shell of Fe3O4@PCA-b-PEG leads to immobilized palladium nanoparticles. The morphology and structural features of the catalyst were characterized using various microscopic and spectroscopic techniques. The catalyst was effectively used in the palladium-catalysed Mizoroki–Heck coupling reaction in water as a green solvent. In addition, the catalyst can be easily recovered from the reaction mixture by applying an external magnetic field and reused for more than ten consecutive cycles without much loss in activity, exhibiting an example of a sustainable and green methodology.
Design of CID-cleavable protein cross-linkers: Identical mass modifications for simpler sequence analysis
Kandur, Wynne V.,Kao, Athit,Vellucci, Danielle,Huang, Lan,Rychnovsky, Scott D.
, p. 9793 - 9807 (2015/10/05)
The cross-linking Mass Spectrometry (XL-MS) technique has enormous potential for studying the interactions between proteins, and it can provide detailed structural information about the interaction interfaces in large protein complexes. Such information h
