3945-85-5

Basic information

• Product Name: Benzene, 4-(3-bromopropyl)-1,2-dimethoxy-
• Synonyms: 2-Nitro-1-<3-brom-propyl>-benzol
• CAS NO: 3945-85-5
• Molecular Formula: C11H15BrO2
• Molecular Weight: 259.143
• Mol File: 3945-85-5.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Benzene, 4-(3-bromopropyl)-1,2-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 4-(3-bromopropyl)-1,2-dimethoxy-(3945-85-5)
• EPA Substance Registry System: Benzene, 4-(3-bromopropyl)-1,2-dimethoxy-(3945-85-5)

Safety Data

• Hazardous Substances Data: 3945-85-5(Hazardous Substances Data)

Upstream product

• 93-15-2 1,2-dimethoxy-4-(2-propenyl)benzene 
• 14737-89-4 3,4-dimethoxy-trans-cinnamic acid 
• 1634-04-4 tert-butyl methyl ether 
• 3929-47-3 3-(3,4-dimethoxyphenyl)-1-propanol 
• 2107-70-2 3,4-methoxycinnamic acid 
• 61871-67-8 3-(3,4-Dimethoxyphenyl)propanal 
• 105174-63-8 3-bromo-1-(3,4-dimethoxyphenyl)propan-1-one 
• 91-16-7 1,2-dimethoxybenzene 
• 2316-26-9 3,4-dimethoxycinnamic acid 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 100157-46-8 3-(3,4-dimethoxyphenyl)-1,1-ethylendioxy-2-propene 
• 100157-47-9 3-(3,4-dimethoxyphenyl)-1,1-ethylendioxypropane 

Downstream Products

• 68081-10-7 1,5-Bis(3,4-dimethoxyphenyl)-2-methyl-2-pentanol 
• 123014-98-2 4-[3-(3,4-dimethoxyphenyl)propoxy]benzoic acid ethyl ester 
• 1165952-72-6 N-[3'-(3'',4''-dimethoxyphenyl)propyl]-4-vinyloxyazetidin-2-one 
• 74027-78-4 4-(3,4-dimethoxyphenyl)butanamine 
• 57293-20-6 <3-(3,4-dimethoxyphenyl)propyl>triphenylphosphonium bromide 

Relevant articles and documents

Inter-and intra-molecular organocatalysis of sn2 fluorination by crown ether: Kinetics and quantum chemical analysis

We present the intra-and inter-molecular organocatalysis of SN2 fluorination using CsF by crown ether to estimate the efficacy of the promoter and to elucidate the reaction mechanism. The yields of intramolecular SN2 fluorination of

Structural optimization of natural product nordihydroguaretic acid to discover novel analogues as AcrB inhibitors

Drug efflux pumps confer multidrug resistance to dangerous bacterial pathogens which makes these proteins promising drug targets. Herein, we present initial chemical optimization and structure-activity relationship (SAR) data around a previously described efflux pump inhibitor, nordihydroguaretic acid (NDGA). Four series of novel NDGA analogues that target Escherichia coli AcrB were designed, synthesized and evaluated for their ability to potentiate the activity of antibiotics, to inhibit AcrB-mediated substrate efflux and reduce off-target activity. Nine novel structures were identified that increased the efficacy of a panel of antibiotics, inhibited drug efflux and reduced permeabilization of the bacterial outer and inner membranes. Among them, WA7, WB11 and WD6 possessing broad-spectrum antimicrobial sensitization activity were identified as NDGA analogues with favorable properties as potential AcrB inhibitors, demonstrating moderate improvement in potency as compared to NDGA. In particular, WD6 was the most broadly active analogue improving the activity of all four classes of antibacterials tested.

Investigation of dopamine analogues: Synthesis, mechanistic understanding, and structure-property relationship

Dopamine, perhaps the simplest molecule that covalently links catechol and amine, together with its derivatives, has shown impressive adhesive and coating properties with its polymers. However, the scope of the molecules is rather limited, and the polymer