3947-52-2

Usage

Uses

Used in Pharmaceutical Industry:
3-(Chloromethyl)piperidine hydrochloride is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its reactivity allows for the creation of diverse drug molecules, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(Chloromethyl)piperidine hydrochloride is utilized as a precursor in the synthesis of agrochemicals. Its role in creating a range of chemical entities makes it instrumental in developing products for agricultural applications, such as pesticides and herbicides.
Used in Organic Synthesis:
3-(Chloromethyl)piperidine hydrochloride is employed as a building block in organic synthesis. Its versatile reactivity enables the construction of a broad spectrum of organic compounds, which can be applied across different industries, including but not limited to pharmaceuticals, materials science, and specialty chemicals.

Upstream product

• 4606-65-9 3-(hydroxymethy)piperidine 

Downstream Products

• 906073-55-0 3-piperidinylmethanesulfonic acid 

Relevant academic research and scientific papers

Methods and compositions for treating amyloid-related diseases

Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.

3-(methyleneaminoxy)methylpiperidine derivatives as uptake inhibitors of biogenic amines in the brain synaptosomal fraction

A series of 3-(methyleneaminoxy)methylpiperidines (5a-h) and their corresponding N-methyl derivatives (6a-h) with a variety of substituents on the imino carbon were synthesized and tested for their potential antidepressant properties; their capacity to inhibit the re-uptake of biogenic amines (NA, 5-HT and DA) in rabbit brain synaptosomal fractions was also evaluated.The biological results obtained for the piperidine derivatives 5a-h and 6a-h and viloxazine 1, the reference drug, on the 3 re-uptake systems revealed that compounds 5 and 6 are generally able to inhibitbiogenic amine uptake.The IC50 values for 5 and 6 were often lower than that of viloxazine 1, in particular for the serotonin- and/or dopamine-uptake systems.A higher activity was found for compounds substituted with at least one phenyl ring on the imino carbon with respect to completely aliphatic systems, and for N-unsubstituted compounds with respect to N-methyl-substituted compounds. 3-(methyleneaminoxy)methylpiperidine derivative / NA uptake inhibitor / 5-HT uptake inhibitor / DA uptake inhibitor / antidepressant drug