394735-63-8

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 225517-15-7 (S)-N^α-(tert-butyloxycarbonyl)-4-hydroxyphenylglycine methyl ester 
• 676596-50-2 (S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxycyclohexyl)acetate 
• 848498-04-4 (S)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-oxocyclohexyl)acetate 

Downstream Products

• 1616257-33-0 (S)-tert-butyl (1-(4,4-difluorocyclohexyl)-2-hydroxyethyl)carbamate 
• 1822546-08-6 (S)-2-((tert-butoxycarbonyl)amino)-2-(4,4-difluorocyclohexyl)acetic acid 

Relevant academic research and scientific papers

IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17

The present application discloses compounds having the following formula: (I), or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.

INDOLE CARBOXAMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS

The invention relates to indole carboxamide derivatives of formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.