39478-47-2

Usage

Derivation

Derived from acetic acid

Primary Use

Reagent in organic synthesis

Specific Applications

Acetylation of alcohols and amines
Production of pharmaceuticals, dyes, and perfumes
Manufacturing of plastics and other organic chemicals

Physical Characteristics

Colorless liquid
Strong, pungent odor

Reactivity

Highly reactive
Easily undergoes hydrolysis in the presence of water

Hydrolysis Products

Forms acetic acid and hydrogen chloride

Handling and Storage

Requires extreme care
Use of appropriate safety measures and protective equipment

Hazards

Corrosive nature

InChI:InChI=1/C8H8ClNO/c9-8(11)7(10)6-4-2-1-3-5-6/h1-5,7H,10H2

Upstream product

• 2835-06-5 phenylglycin 

Downstream Products

• 24701-70-0 3-methoxymethyl-7-D-phenylglycylamino-3-cephem-4-carbonsaeure 
• 26255-40-3 3-Ethoxymethyl-7-D-phenylglycylamino-3-cephem-4-carbonsaeure 
• 24461-61-8 phenylglycine methyl ester 
• 90913-34-1 (6R,7R)-7-(2-Amino-2-phenyl-acetylamino)-4-[1-methoxycarbonyl-meth-(Z)-ylidene]-3-methyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 98230-25-2 Potassium; (2S,5R,6S)-6-[3-(2-amino-2-phenyl-acetyl)-thioureido]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate 

Relevant academic research and scientific papers

Antiplasmodial, β-haematin inhibition, antitrypanosomal and cytotoxic activity in vitro of novel 4-aminoquinoline 2-imidazolines

A novel series of 4-aminoquinoline-containing 2-imidazolines were synthesized via a one-pot 3-component condensation reaction of amine, aldehyde and isocyanoacetate. The products were obtained in high yield as well as purity and were evaluated directly against two strains of Plasmodium falciparum and Trypanosoma brucei. Compound 21 was the most active across all parasites with ED50 = 3.3 nM against a chloroquine (CQ)-sensitive 3D7 strain, ED50 = 33 nM against a CQ-resistant K1 strain and ED50 = 70 nM against T. brucei. Several compounds were able to inhibit formation of β-haematin in vitro, suggesting haemozoin formation in the malaria parasite as a possible target. On the other hand, evaluation against a human KB cell line revealed that the compounds were generally non-cytotoxic to the host cells.

MAYTANSINOID ANALOGS AS ANTITUMOR AGENTS

Ansamycin analogs, including maytansinoid analogs, and their use in treating cell proliferative diseases and conditions, and in particular, for use as antitumor agents.