3948-64-9Relevant academic research and scientific papers
A Visible-Light-Driven, Metal-free Route to Aromatic Amides via Radical Arylation of Isonitriles
Malacarne, Marco,Protti, Stefano,Fagnoni, Maurizio
supporting information, p. 3826 - 3830 (2017/11/15)
The photochemical metal-free carboamidation of aryl radicals has been exploited for the preparation of aromatic amides, including hetero- and polyaromatic derivatives, under visible light irradiation of arylazo sulfones in the presence of isocyanides in aqueous acetonitrile. The process was useful for the smooth preparation of the antidepressant moclobemide. (Figure presented.).
Comparative study of dG affinity vs. DNA methylation modulating properties of side chain derivatives of procainamide: Insight into its DNA hypomethylating effect
Gawade,Chakravarty,Debgupta,Sangtani,Narwade,Gonnade,Puranik,Deobagkar
, p. 5350 - 5358 (2016/02/05)
Procainamide derivatives have been synthesized to investigate the role of side chains in modulating the DNA methylation level in cancer cells and gain insight into its mechanism of action. The synthesized derivatives comprised of flexible (dimethyl), cons
TYK2 INHIBITORS AND USES THEREOF
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Paragraph 00493; 00494, (2015/09/28)
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
AURORA KINASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF
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Page/Page column 66, (2012/10/18)
Described herein are inhibitors of Aurora kinase and their use in the treatment of cancer. Methods of screening for selective inhibitors of Aurora kinases are also disclosed.
Exploration of secondary and tertiary pharmacophores in unsymmetrical N,N′-diaryl urea inhibitors of soluble epoxide hydrolase
Anandan, Sampath-Kumar,Gless, Richard D.
scheme or table, p. 2740 - 2744 (2010/07/15)
The impact of various secondary and tertiary pharmacophores on in vitro potency of soluble epoxide hydrolase (sEH) inhibitors based on the unsymmetrical urea scaffold 1 is discussed. N,N′-Diaryl urea inhibitors of soluble epoxide hydrolase exhibit subtle variations in inhibitory potency depending on the secondary pharmacophore but tolerate considerable structural variation in the second linker/tertiary pharmacophore fragment.
Process for the preparation of aqueous diazonium salt solutions
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, (2008/06/13)
An aqueous solution of diazonium salts is prepared in the absence of organic solvents by reducing a water-soluble aromatic nitro compound in aqueous solution with hydrogen and a hydrogenation catalyst to give the aromatic amino compound, and diazotizing this amino compound in the aqueous solution.
