39488-46-5Relevant academic research and scientific papers
Polythiophene derivative electrochromic material and preparation method thereof
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Paragraph 0008; 0114; 0115, (2017/09/01)
The invention discloses a polythiophene derivative electrochromic material and a preparation method thereof. The polythiophene derivative electrochromic material has the following molecular structure shown as the accompanying drawing, wherein n is 1 to 3; m is 5 to 18. Thiophene oligomer terthienyl, sexithiophene and nine thiophene are respectively used as raw materials; two aldehyde groups are respectively introduced to the tail ends of the three kinds of polythiophene through Vilsmeier-Haack reaction; cyanoacetic acid is firstly subjected to esterification and then takes a reaction with alkylamine to generate 2-cyano-acetylalkylamine; products obtained through the two steps of reaction is subjected to Knoevenagel condensation to obtain a target product. The prepared polythiophene derivative can form gel; a device prepared by using the gel as the electrochromic material does not need a film forming process; in addition, the problem that the device can easily generate liquid leakage due to the use of liquid electrolyte can also be solved.
Design of a novel thiophene inhibitor of 15-lipoxygenase-1 with both anti-inflammatory and neuroprotective properties
Eleftheriadis, Nikolaos,Poelman, Hessel,Leus, Niek G.J.,Honrath, Birgit,Neochoritis, Constantinos G.,Dolga, Amalia,D?mling, Alexander,Dekker, Frank J.
, p. 786 - 801 (2016/08/30)
The enzyme 15-lipoxygenase-1 (15-LOX-1) plays a dual role in diseases with an inflammatory component. On one hand 15-LOX-1 plays a role in pro-inflammatory gene expression and on the other hand it has been shown to be involved in central nervous system (CNS) disorders by its ability to mediate oxidative stress and damage of mitochondrial membranes under hypoxic conditions. In order to further explore applications in the CNS, novel 15-LOX-1 inhibitors with favorable physicochemical properties need to be developed. Here, we present Substitution Oriented Screening (SOS) in combination with Multi Component Chemistry (MCR) as an effective strategy to identify a diversely substituted small heterocyclic inhibitors for 15-LOX-1, denoted ThioLox, with physicochemical properties superior to previously identified inhibitors. Ex?vivo biological evaluation in precision-cut lung slices (PCLS) showed inhibition of pro-inflammatory gene expression and in?vitro studies on neuronal HT-22?cells showed a strong protection against glutamate toxicity for this 15-LOX-1 inhibitor. This provides a novel approach to identify novel small with favorable physicochemical properties for exploring 15-LOX-1 as a drug target in inflammatory diseases and neurodegeneration.
