395-35-7

Usage

Chemical Properties

white to almost white powder

General Description

Bismuth-catalyzed oxidation of 4-(trifluoromethyl)mandelic acid has been reported.

InChI:InChI=1/C9H7F3O3/c10-9(11,12)6-3-1-5(2-4-6)7(13)8(14)15/h1-4,7,13H,(H,14,15)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 124-38-9 carbon dioxide 

Downstream Products

• 51380-14-4 (R)-4-(trifluoromethyl)mandelic acid 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 940952-12-5 S-acetyl-α-(p-trifluoromethylphenyl)-α-mercaptoacetic acid 
• 940952-42-1 4-(p-trifluoromethylphenyl)-1,3,2-oxathiazolylium-5-olate 
• 1033777-85-3 2-hydroxy-2-(4-(trifluoromethyl)phenyl)acetyl chloride 
• 1033776-68-9 2-hydroxy-N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-(4-trifluoromethylphenyl)acetamide 
• 196302-06-4 (S)-4-(trifluoromethyl)mandelic acid 
• 1158519-46-0 C₁₆H₁₁F₆NO₂ 
• 1210859-19-0 1-[2-(2-Fluoro-phenyl)-pyrrolidin-1-yl]-2-hydroxy-2-(4-trifluoromethyl-phenyl)-ethanone 
• 1891-90-3 p-trifluoromethylbenzamide 

Relevant academic research and scientific papers

Photocatalytic Carbinol Cation/Anion Umpolung: Direct Addition of Aromatic Aldehydes and Ketones to Carbon Dioxide

We have developed a new photocatalytic umpolung reaction of carbonyl compounds to generate anionic carbinol synthons. Aromatic aldehydes or ketones reacted with carbon dioxide in the presence of an iridium photocatalyst and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzimidazole (DMBI) as a reductant under visible-light irradiation to furnish the corresponding α-hydroxycarboxylic acids through nucleophilic addition of the resulting carbinol anions to electrophilic carbon dioxide.

7-α-Amino-substituted acylamino-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids

Certain 7-acylamido-3-(1-carboxy-loweralkyl-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acids and their salts and easily hydrolyzed esters of the 4-carboxyl group were synthesized and found to be potent antibacterial agents which exhibited good aqueous solubility. In a preferred embodiment the 7-substituent was 2'-aminomethylphenylacetamido.

7-(D-α-Hydroxy-2-arylacetamido)-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo-[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acids and derivatives

7-(D-α-Hydroxy-2-arylacetamido)-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acids and derivatives containing blocking groups on the α-hydroxy group and their nontoxic, pharmaceutically acceptable salts are valuable as antibacterial agents and are particularly valuable as therapeutic agents in poultry and in animals, including man, in the treatment of infectious diseases caused by many Gram-positive and Gram-negative bacteria. A preferred compound is 7-(D-mandelamido)-3-(2-carboxyalkyl-2,3-dihydro-s-triazolo[4,3-b]pyridazin-3-on-6-ylthiomethyl)-3-cephem-4-carboxylic acid.

7-(D-α-Hydroxy-2-arylacetamido)-3-(tetrazolo-[4,5-b]pyridazin-6-ylthiomethyl)-3-cephem-4-carboxylic acids

7-(D-α-Hydroxy-2-arylacetamido)-3-(tetrazolo-[4,5-b]pyridazin-6-ylthiomethyl)-3-cephem-4-carboxylic acids and their nontoxic, pharmaceutically acceptable salts are valuable as antibacterial agents and are particularly valuable as therapeutic agents in poultry and animals, including man, in the treatment of infectious diseases caused by many Gram-positive and Gram-negative bacteria.