395-47-1

Basic information

• Product Name: 2-TRIFLUOROMETHYLPHENYL MAGNESIUM BROMIDE
• CAS NO: 395-47-1
• Molecular Formula: C7H4BrF3Mg
• Molecular Weight: 249.313
• Mol File: 395-47-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-TRIFLUOROMETHYLPHENYL MAGNESIUM BROMIDE (CAS DataBase Reference)
• NIST Chemistry Reference: 2-TRIFLUOROMETHYLPHENYL MAGNESIUM BROMIDE (395-47-1)
• EPA Substance Registry System: 2-TRIFLUOROMETHYLPHENYL MAGNESIUM BROMIDE (395-47-1)

Safety Data

• Safety Statements: Solutions in org solvs (e.g., ether, benzene) may explode above 40°C. When heated to decomposition it emits toxic fumes of Fsup xmlns="">−/sup> and Brsup xmlns="">−/sup>. See also a target="_blank" href="lom/card_sa.tes?href=content/sax0004/sdp03880.xml&view=print">BROMIDES/a>, a target="_blank" href="lom/card_sa.tes?href=content/sax0016/sdp15863.xml&view=print">MAGNESIUM COMPOUNDS/a>, and a target="_blank" href="lom/card_sa.tes?href=content/sax0013/sdp12465.xml&view=print">FLUORIDES/a>.
• HazardClass: 3
• Hazardous Substances Data: 395-47-1(Hazardous Substances Data)

Upstream product

• 392-83-6 o-trifluoromethylphenyl bromide 
• 7439-95-4 magnesium 

Downstream Products

• 115171-06-7 C₁₇H₂₃F₃N₂O₄ 
• 91993-93-0 (4R,5R)-2,4,7-Trimethyl-5-(2-trifluoromethyl-phenyl)-4,5-dihydro-1H-azepine-3,6-dicarboxylic acid dimethyl ester 
• 91993-94-1 (4S,5R)-2,4,7-Trimethyl-5-(2-trifluoromethyl-phenyl)-4,5-dihydro-1H-azepine-3,6-dicarboxylic acid dimethyl ester 
• 108303-78-2 4-Methyl-2-oxo-7-(2-trifluoromethyl-phenyl)-2,3,6,7-tetrahydro-1H-[1,3]diazepine-5-carboxylic acid ethyl ester 
• 89664-09-5 (4-chlorophenyl)-(2-trifluoromethyl-phenyl)-methanol 
• 17113-80-3 (CH₃)3SnC₆H₄-o-CF₃ 
• 591215-77-9 (methyl)2Sn(C₆H₄-o-CF₃)2 
• 880653-42-9 bis[4-(2-trifluoromethylphenyl)-2-methyl-1H-inden-1-yl](dimethyl)silane 
• 940868-53-1 1-[1-(2-trifluoromethyl-phenyl)-cyclobutyl]-propan-2-one 
• 17408-14-9 1-(2-(trifluoromethyl)phenyl)ethan-1-one 
• 441072-21-5 2-(2-(trifluoromethyl)phenyl)pyridine 
• 727-98-0 phenyl[2-(trifluoromethyl)phenyl]methanol 
• 91993-87-2 2,7-Dimethyl-4-(2-trifluoromethyl-phenyl)-4,5-dihydro-1H-azepine-3,6-dicarboxylic acid dimethyl ester 
• 346-06-5 (2-(trifluoromethyl)phenyl)methanol 

Relevant articles and documents

Nickel-Catalyzed Cross-Coupling of Functionalized Organo manganese Reagents with Aryl and Heteroaryl Halides Promoted by 4-Fluorostyrene

A catalytic system consisting of Ni(acac) 2 (5 mol%) and 4-fluorostyrene (20 mol%) allows a convenient cross-coupling of functionalized organomanganese reagents with a variety of aryl and heteroaryl halides leading to polyfunctionalized diaryl- and arylheteroarylmethane derivatives.

Formation of 2-trifluoromethylphenyl grignard reagent via magnesium-halogen exchange: Process safety evaluation and concentration effect

The thermal stability profile for a solution of 2-trifluoromethylphenyl magnesium chloride at 1.5Mconcentration in THF was determined using an Advanced Reactive System Screening Tool (ARSST). The solution generated by employing Knochel's magnesium-halogen