395-47-1

Upstream product

• 392-83-6 o-trifluoromethylphenyl bromide 
• 7439-95-4 magnesium 

Downstream Products

• 108303-78-2 4-Methyl-2-oxo-7-(2-trifluoromethyl-phenyl)-2,3,6,7-tetrahydro-1H-[1,3]diazepine-5-carboxylic acid ethyl ester 
• 73475-34-0 [2-(trifluoromethyl)phenyl](diphenyl)methanol 
• 395-44-8 o-trifluoromethylbenzyl bromide 
• 89664-09-5 (4-chlorophenyl)-(2-trifluoromethyl-phenyl)-methanol 
• 591215-77-9 (methyl)2Sn(C₆H₄-o-CF₃)2 
• 880653-42-9 bis[4-(2-trifluoromethylphenyl)-2-methyl-1H-inden-1-yl](dimethyl)silane 
• 940868-53-1 1-[1-(2-trifluoromethyl-phenyl)-cyclobutyl]-propan-2-one 
• 441072-21-5 2-(2-(trifluoromethyl)phenyl)pyridine 
• 17408-14-9 1-(2-(trifluoromethyl)phenyl)ethan-1-one 
• 1620658-24-3 2-(aminomethyl)-6-({bis[2-(trifluoromethyl)phenyl]phosphoryl}methyl)pyridine 1-oxide 

Relevant academic research and scientific papers

Nickel-Catalyzed Cross-Coupling of Functionalized Organo manganese Reagents with Aryl and Heteroaryl Halides Promoted by 4-Fluorostyrene

A catalytic system consisting of Ni(acac) 2 (5 mol%) and 4-fluorostyrene (20 mol%) allows a convenient cross-coupling of functionalized organomanganese reagents with a variety of aryl and heteroaryl halides leading to polyfunctionalized diaryl- and arylheteroarylmethane derivatives.

Preparation of Trifluoromethylphenyl Magnesium Halides in the Presence of LiCl and Synthesis of 2′-Trifluoromethyl-Aromatic Ketones

The effect of LiCl-promoted insertion of magnesium turnings into halogenated-trifluoromethylbenzenes for Grignard reagent synthesis was investigated. In the presence of less than 1.0 equiv of LiCl, chloro(trifluoromethyl)benzene Grignard reagents were easily generated. The 2-trifluoromethylphenyl magnesium chloride Grignard reagent was obtained in high yield and 2′-trifluoromethyl-substituted aromatic ketone was synthesized through reaction of the obtained Grignard reagent with a carboxylic anhydride in an 83% yield.

Formation of 2-trifluoromethylphenyl grignard reagent via magnesium-halogen exchange: Process safety evaluation and concentration effect

The thermal stability profile for a solution of 2-trifluoromethylphenyl magnesium chloride at 1.5Mconcentration in THF was determined using an Advanced Reactive System Screening Tool (ARSST). The solution generated by employing Knochel's magnesium-halogen

AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDERS

Compounds of formula (I) and their use in therapy, particularly for the treatment of a disorder mediated by CB1 receptors such as obesity: Formuila (I) wherein: R1 and R2 are independently selected from aryl; and R3 is hydrogen or alkyl; or a pharmaceutically acceptable salt or prodrug thereof, wherein at least one of R1 and R2 has a non-hydrogen substituent in the ortho-position(s) thereof relative to the point of attachment to the [-CH-0-] group.