395065-66-4

Upstream product

• 456-48-4 3-Fluorobenzaldehyde 
• 335314-64-2 1-(3-fluorophenyl)-prop-2-enyl methyl carbonate 
• 1026720-66-0 2-[(R)-1-(3-Fluoro-phenyl)-allyl]-malonic acid 

Downstream Products

• 395065-67-5 methyl (5S)-5-(3-fluorophenyl)-3-oxo-6-heptenoate 
• 313502-76-0 (+)-trans-3-hydroxymethyl-4-(3-fluorophenyl)cyclopentan-1-one 
• 395065-68-6 methyl (5S)-2-diazo-5-(3-fluorophenyl)3-oxo-6-heptenoate 

Relevant academic research and scientific papers

Development of a new and practical route to chiral 3,4-disubstituted cyclopentanones: Asymmetric alkylation and intramolecular cyclopropanation as key C-C bond-forming steps

An efficient and practical asymmetric synthesis of (+)-trans-3-hydroxymethyl-4-(3-fluorophenyl)-cyclopentanone (1) is described. An asymmetric Mo-catalyzed alkylation reaction was used to establish the first stereocenter and a Cu-catalyzed intramolecular diastereoselective cyclopropanation reaction was used to set the second stereocenter. The last step involved a one-pot ring-opening/deprotection/hydrolysis/decarboxylation sequence that furnished the desired product in good yield.

N-cyclopentyl modulators of chemokine receptor activity

The present invention is directed to compounds of the formula I: (wherein R1, R3, R4, R5, R6, R7, R8, X, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-5 and/or CCR-3.