3951-10-8

Basic information

• Product Name: 4-METHOXYPHENYLACETIC ANHYDRIDE
• Synonyms: 4-METHOXYPHENYLACETIC ANHYDRIDE;4-METHOXYPHENYLACETIC ANHYDRIDE 98+%;[2-(4-methoxyphenyl)acetyl] 2-(4-methoxyphenyl)acetate
• CAS NO: 3951-10-8
• Molecular Formula: C₁₈H₁₈O₅
• Molecular Weight: 314.33
• Mol File: 3951-10-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 76°C
• Appearance: /
• Refractive Index: 1.553
• CAS DataBase Reference: 4-METHOXYPHENYLACETIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXYPHENYLACETIC ANHYDRIDE(3951-10-8)
• EPA Substance Registry System: 4-METHOXYPHENYLACETIC ANHYDRIDE(3951-10-8)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 3951-10-8(Hazardous Substances Data)

Usage

General Description

4-Methoxyphenylacetic anhydride is a chemical compound with the molecular formula C10H11NO3. It is an acylating agent and a key intermediate in the synthesis of pharmaceuticals and biologically active compounds. 4-METHOXYPHENYLACETIC ANHYDRIDE is commonly used in organic chemistry as a reagent for the preparation of various molecules, including pharmaceuticals, pesticides, and fragrances. It is also utilized in the synthesis of chiral intermediates and building blocks for medicinal and agrochemical products. Additionally, 4-Methoxyphenylacetic anhydride has potential applications in the development of new materials and the field of organic synthesis. Its unique properties and versatile reactivity make it an important compound in the realms of research, development, and production in the chemical industry.

InChI:InChI=1/C18H18O5/c1-21-15-7-3-13(4-8-15)11-17(19)23-18(20)12-14-5-9-16(22-2)10-6-14/h3-10H,11-12H2,1-2H3

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 
• 42766-36-9 potassium p-methoxyphenylacetate 
• 17274-18-9 sodium 2-(4-methoxyphenyl)acetate 
• 4693-91-8 4-methoxyphenyl-acetic chloride 

Downstream Products

• 3173-00-0 7-methoxy-3-(4-methoxyphenyl)-2H-chromen-2-one 
• 123731-50-0 5,7-dimethoxy-3-(4-methoxyphenyl)-2H-1-benzopyran-2-one 
• 113769-77-0 3-(4-methoxyphenyl)-6-methyl-2H-chromen-2-one 
• 18255-07-7 1-methoxy-4-<(phenylseleno)methyl>benzene 
• 2746-25-0 p-Methoxybenzyl bromide 
• 23000-33-1 3-(4-methoxyphenyl)coumarin 
• 5023-67-6 4-methoxybenzyl phenyl sulfide 
• 1207603-64-2 6-(4-methoxybenzylidene)-3,4,6,7-tetrahydro-1H-spiro[chromeno[3,4-b]indole-2,2'-[1,3]dioxolane] 
• 54954-37-9 2-(4-methoxyphenyl)-N-methyl-N-phenylacetamide 
• 102586-43-6 ethyl 3-oxo-2,4-bis(4-methoxyphenyl)butanoate 

Relevant articles and documents

Regioselective C2- and C8-acylation of 5,11-dihydroindolo[3,2-b]carbazoles and the synthesis of their 2,8-bis(quinoxalinyl) derivatives

An efficient approach for the double acetylation of 5,11-dihexyl-6,12-di(hetero)aryl-substituted 5,11-dihydroindolo[3,2-b]carbazoles with acetic anhydride in the presence of boron trifluoride etherate has been developed, thus affording the corresponding 2

Enantioselective Synthesis of 3,5,6-Substituted Dihydropyranones and Dihydropyridinones using Isothiourea-Mediated Catalysis

The scope of dihydropyranone and dihydropyridinone products accessible by isothiourea-catalyzed processes has been expanded and explored through the use of 2-N-tosyliminoacrylates and 2-aroylacrylates in a Michael addition-lactonization/lactamization cascade reaction. Notably, to ensure reproducibility it is essential to use homoanhydrides as ammonium enolate precursors with 2-aroyl acrylates, while carboxylic acids can be used with 2-N-tosyliminoacrylates, delivering a range of 3,5,6-substituted dihydropyranones and dihydropyridinones with high enantioselectivity (typically >90 % ee). The derivatization of the heterocyclic core of a 3,5,6-substituted dihydropyranone through hydrogenation is also reported.

Asymmetric Isothiourea-Catalysed Formal [3+2] Cycloadditions of Ammonium Enolates with Oxaziridines

A highly enantioselective Lewis base-catalysed formal [3+2] cycloaddition of ammonium enolates and oxaziridines to give stereodefined oxazolidin-4-ones in high yield is described. Employing an enantioenriched oxaziridine in this process leads to a matched/mis-matched effect with the isothiourea catalyst and allowed the synthesis of either syn- or anti-stereodefined oxazolidin-4-ones in high d.r., yield and ee. Additionally, the oxazolidin-4-one products have been derivatised to afford functionalised enantioenriched building blocks.