39510-08-2

Upstream product

• 1068-55-9 isopropylmagnesium chloride 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 100-66-3 methoxybenzene 
• 2040-20-2 4-methoxyisobutyrophenone 
• 39510-07-1 2-Cyano-3-isopropyl-3-(p-methoxyphenyl)propionsaeureaethylester 

Downstream Products

• 39510-11-7 3-Isopropyl-3-(p-methoxyphenyl)-1-propanol 
• 378233-73-9 3-(4-methoxy-phenyl)-4-methyl-pentanoyl chloride 
• 39510-12-8 4-Isopropyl-4-(p-methoxyphenyl)butyronitril 
• 378233-72-8 2-diazo-5-(4'-methoxyphenyl)-6-methylheptan-3-one 

Relevant academic research and scientific papers

Ruthenium-catalyzed intramolecular arene C(sp2)-H amidation for synthesis of 3,4-dihydroquinolin-2(1 H)-ones

We report the [Ru(p-cymene)(l-proline)Cl] ([Ru1])-catalyzed cyclization of 1,4,2-dioxazol-5-ones to form dihydroquinoline-2-ones in excellent yields with excellent regioselectivity via a formal intramolecular arene C(sp2)-H amidation. The reactions of the 2- and 4-substituted aryl dioxazolones proceeds initially through spirolactamization via electrophilic amidation at the arene site, which is para or ortho to the substituent. A Hammett correlation study showed that the spirolactamization is likely to occur by electrophilic nitrenoid attack at the arene, which is characterized by a negative ρ value of -0.73.

Construction of enantioenriched 9H-Fluorene frameworks via a cascade reaction involving remote vinylogous dynamic kinetic resolution

The benzylic C-H group of α,α-dicyanoolefins from 3-substituted 1-indanones could be significantly activated via transmission along the aromatic system, thus enabling dynamic kinetic resolution via a traditional reversible deprotonation- protonation process. Enantioenriched 9-substituted 9H-fluorene frameworks were finally constructed through an asymmetric vinylogous Michael addition to nitroolefins, followed by a cascade cyclization and oxidative aromatization process, under the catalysis of a chiral bifunctional thiourea-tertiary amine.