3952-69-0

Basic information

• Product Name: 5-HYDROXY-4H-CHROMEN-4-ONE
• Synonyms: 5-HYDROXY-4H-CHROMEN-4-ONE;5-Hydroxy-4H-chromen-4-one, Tech.
• CAS NO: 3952-69-0
• Molecular Formula: C₉H₆O₃
• Molecular Weight: 162.14
• Mol File: 3952-69-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 127 °C
• Boiling Point: 312.3°Cat760mmHg
• Flash Point: 132.4°C
• Appearance: /
• Density: 1.403g/cm³
• Vapor Pressure: 0.00029mmHg at 25°C
• Refractive Index: 1.64
• PKA: 6.83±0.20(Predicted)
• CAS DataBase Reference: 5-HYDROXY-4H-CHROMEN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-HYDROXY-4H-CHROMEN-4-ONE(3952-69-0)
• EPA Substance Registry System: 5-HYDROXY-4H-CHROMEN-4-ONE(3952-69-0)

Safety Data

• Hazardous Substances Data: 3952-69-0(Hazardous Substances Data)

Usage

General Description

5-HYDROXY-4H-CHROMEN-4-ONE, also known as 5-hydroxycoumarin, is a chemical compound with a molecular formula of C9H6O3 and a molecular weight of 162.14 g/mol. It is a derivative of coumarin and is commonly found in plants such as tonka beans and sweet woodruff. 5-HYDROXY-4H-CHROMEN-4-ONE has been studied for its potential medicinal properties, including its antioxidant, anti-inflammatory, and anti-cancer effects. It has also been investigated for its potential use in the treatment of diabetes and its ability to protect against various neurological disorders. Additionally, this compound has been used in the development of pharmaceuticals, as well as in the synthesis of other organic compounds.

InChI:InChI=1/C9H6O3/c10-6-2-1-3-8-9(6)7(11)4-5-12-8/h1-5,10H

Upstream product

• 699-83-2 2,6-dihydroxylacetophenone 
• 124-63-0 methanesulfonyl chloride 
• 122-51-0 orthoformic acid triethyl ester 
• 108-46-3 recorcinol 
• 68-12-2 N,N-dimethyl-formamide 
• 109-94-4 formic acid ethyl ester 
• 118-93-4 o-hydroxyacetophenone 
• 491-38-3 1-benzopyran-4(4H)-one 

Downstream Products

• 133992-43-5 3,4-dihydrofuro<4,3,2-de><1>benzopyran 
• 13849-32-6 3,4-dihydro-5-hydroxy-2H-1-benzopyran 
• 59887-87-5 5-methoxy-4H-chromen-4-one 
• 13849-19-9 5-hydroxy-3,4-dihydro-2H-1-benzopyran-4-one 

Relevant articles and documents

PYRAZOLYLBENZENE-1,3-DIOLS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 18 AND IN COMBINATION WITH TRANSIENT RECEPTOR POTENTIAL VANILLOID 1

The present invention relates to pyrazolylbenzene-1,3-diols as cannabidiol derivatives, its use for the manufacture of a medicament, and more particularly, to the use of this medicament for the treatment and/or prevention of a disorder associated with the GPR18 and/or TRPV1 receptors and the use of these compounds for pharmacological assays related to GPR18 and/or TRPV1.

Second Generation Total Synthesis of (–)-Preussochromone D

An improved enantioselective synthesis of the natural product (–)-preussochromone D (3) and first insights into a possible route to the trans-preussochromones E and F are described. Starting from commercially available 5-hydroxy-4H-chromen-4-one, two ster