39531-35-6

Basic information

• Product Name: 1-Piperidinecarboxamide, N-(phenylmethyl)-
• CAS NO: 39531-35-6
• Molecular Formula: C13H18N2O
• Molecular Weight: 218.299
• Mol File: 39531-35-6.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxamide, N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxamide, N-(phenylmethyl)-(39531-35-6)
• EPA Substance Registry System: 1-Piperidinecarboxamide, N-(phenylmethyl)-(39531-35-6)

Safety Data

• Hazardous Substances Data: 39531-35-6(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 2621-78-5 ethyl N-benzylcarbamate 
• 39896-97-4 benzyl-carbamic acid benzyl ester 
• 3173-56-6 benzyl isothiocyanate 
• 124-38-9 carbon dioxide 
• 622-79-7 benzyl azide 
• 1530-87-6 1-piperidinylcarbonnitrile 
• 100-51-6 benzyl alcohol 
• 17738-04-4 piperidine-1-carboxylic acid allyl ester 
• 100-46-9 benzylamine 
• 42116-44-9 N-tert-butoxycarbonylbenzylamine 
• 88333-03-3 Benzyl isocyanide 
• 5330-97-2 N-hydroxy-2-phenylacetamide 
• 909870-76-4 C₆H₁₀NO⁽¹⁺⁾ 

Downstream Products

• 2158-03-4 1-piperidinecarboxamide 

Relevant articles and documents

P(III)-Assisted Electrochemical Access to Ureas via in situ Generation of Isocyanates from Hydroxamic Acids

An external oxidant-free protocol for the generation of isocyanates from hydroxamic acids assisted by trivalent phosphine under mild electrochemical conditions was reported. The process started with the anodic oxidation of hydroxamic acids, followed by reacting with phosphine to form corresponding alkoxyphosphoniums and subsequent rearrangement with the release of tri-substituted phosphine oxide as the driving force to give isocyanates, which were trapped by N-based nucleophiles to produce various ureas. This method provides a broadly applicable procedure to access isocyanate intermediates under mild electrochemical conditions.

METHOD OF CONVERTING CARBON DIOXIDE INTO CARBONYL COMPOUNDS

The present invention provides a method for fixing carbon dioxide gas as a carbonyl compound represented by formula (3) as depicted by Figure 1 and comprising, purging of carbon dioxide in a solution of a nucleophile represented by the formula (1) in presence of a solvent at a temperature ranging from -40 Degree Celsius to 35 Degree Celsius, followed by adding a reagent at temperature ranging from -40 degree to 35 degree and thereafter adding another nucleophile represented by the formula (2) to obtain carbonyl compound represented by formula (3). The present invention can be advantageously used to obtain commercially important carbonyl compounds and clean unwanted carbon dioxide gas from the atmosphere and industrial effluents.

Facile direct synthesis of unsymmetrical ureas from N-Alloc-, N-Cbz-, and N-Boc-protected amines using DABAL-Me3

A practical synthetic method for the direct synthesis of unsymmetrically substituted ureas from N-Alloc-, N-Cbz-, and N-Boc-protected amines is described. In this study, efficient direct conversion of the Alloc-, Cbz-, and Boc-carbamate compounds to ureas was achieved in the presence of DABAL-Me3, an air stable and easily handled reagent. Using this reaction method, both protected aromatic and aliphatic amines were successfully transformed into various trisubstituted and tetrasubstituted ureas with high yields without side product. Our findings offer promising guidelines for direct preparation of useful ureas from N-Alloc-, N-Cbz-, and N-Boc-carbamates.