39532-30-4

Upstream product

• 98-85-1 1-Phenylethanol 
• 20445-31-2 R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid 
• 20445-33-4 (R)-methoxytrifluoromethylphenylacetyl chloride 
• 1517-69-7 (R)-1-phenylethanol 
• 1122-58-3 dmap 
• 39637-99-5 (S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride 

Relevant academic research and scientific papers

Laboratory scale-up synthesis of chiral carbinols using Rhizopus arrhizus

Rhizopus arrhizus mediated bioreduction was optimized using acetophenone as a model substrate. Various parameters such as bio-processing conditions, reaction time, substrate concentration, temperature, and solvent carrier were studied. This optimized protocol was further exploited for scaled up bioreductions of various prochiral ketones. This study demonstrates the versatility of the fungus Rhizopus arrhizus as a biocatalyst to obtain chiral carbinols in good to excellent yields and selectivities.

Chelated ruthenium complexes of functionalized pentaarylcyclopentadienes

The Pd-catalyzed arylation of tetraphenylcyclopentadiene (7) and the classical "tetracyclone route" are tested as preparative entries to a variety of pentaarylcyclopentadienes 4 monofunctionalized in the ortho-position. The corresponding chelated rutheniu

Preparation of Chlorofluoroacetic Acid Derivatives for the Analysis of Chiral Alcohols

(R)- and (S)-Chlorofluoroacetic acid (CFA) esters of several chiral secondary alcohols have been prepared and compared with the corresponding esters of Mosher's acid.CFA itself is a readily accessible and optically stable acid which gives the expected dia

A simple method for the microscale preparation of Mosher's acid chloride

Mosher's acid is treated with oxalyl chloride in the presence of DMF in hexane. Filtration and concentration provide the acid chloride which is suitable for use without further purification. The procedure is amenable to microscale.

Asymmetric Synthesis of Alpha Substituted Benzyl Alcohols via the Stereoselective Addition of Nucleophiles to Homochiral Tricarbonyl(η6-o-trialkylsilylbenzaldehyde)chromium(0) Complexes

The addition of nucleophiles to tricarbonyl(η6-o-trialkylsilylbenzaldehyde)chromium(0) complexes proceeds with complementary diastereoselectivities in the presence or absence of strong Lewis acids.The ready availability of homochiral aldehyde complexes, via classical resolution with L-valinol, permits the synthesis of alpha substituted benzyl alcohols with high enantiomeric excesses.

Kinetic resolution of racemic alcohols with chiral carboxylic acids and dicyclohexylcarbodiimide

The DCC-esterification method has been used to kinetically resolve racemic mixtures of alcohols. With simple chiral carboxylic acids, such as O-aryl lactic acids, in the presence of various basic catalysts, mixtures of the enantiomerically enriched alcohols (e.e. 50%) and the corresponding esters (d.e. 70%) have been obtained.

Highly stereoselective reduction of methyl ketone complexes of the chiral Lewis acid 5-C5H5)Re(NO)(PPh3)>+ by K(s-C4H9)3BH; synthesis of optically active secondary alcohols and derivatives

Reaction of optically active ketone complexes (+)-(R)-5-C5H5)Re(NO)(PPh3)(η1-O=C(R)CH3)>+BF- (R=CH2CH3, CH(CH3)2, C(CH3)3, C6H5) with K(s-C4H9)3BH gives alkoxide complexes (+)-(RS)-(η5-C5H5)Re(NO)(