39561-94-9

Upstream product

• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 71145-03-4 1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]pyridine-3-carboxylic acid methyl ester 
• 53219-40-2 Fossheim 
• 137481-53-9 6-Methyl-2,4-bis-<2-(trifluormethyl)phenyl>-pyrimidin-5-carbonsaeuremethylester 
• 137481-71-1 2-Amino-2,6-dimethyl-4-<2-(trifluormethyl)phenyl>-pyridin-3-carbonsaeuremethylester 
• 115700-40-8 2,6-Dimethyl-5-nitro-4-<2-(trifluormethyl)phenyl>-pyridin-3-carbonsaeuremethylester 
• 103785-60-0 2,6-Dimethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-oxo-propyl) ester 
• 141600-69-3 (+)-1,4-dihydro-2,6-dimethyl-4-(2-trifluoromethylphenyl)-5-methoxycarbonyl-3-pyridinecarboxylic acid 
• 118432-10-3 3-Cyclopentyl-1,6-dimethyl-4-(3-trifluoromethyl-phenyl)-4,7-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid methyl ester; hydrochloride 
• 88249-98-3 2,6-Dimethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-(2-cyano-ethyl) ester 5-methyl ester 
• 99880-15-6 2,6-Dimethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-methyl ester 5-(2-methyl-[1,3]dioxolan-2-ylmethyl) ester 
• 99880-23-6 2,6-Dimethyl-4-(2-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-cyclopropylmethyl ester 5-methyl ester 

Relevant academic research and scientific papers

Mild and facile cleavage of 2-cyanoethyl ester using sodium sulfide or tetrabutylammonium fluoride. Synthesis of 1,4-dihydropyridine monocarboxylic acids and unsymmetrical 1,4-dihydropyridine dicarboxylates

Several 3-(2-cyanoethyl)-1,4-dihydropyridine carboxylates (16) were prepared in moderate to good yields by means of the Hantzsch reaction. Treatment of these carboxylates with a weak base such as sodium sulfide or tetrabutylammonium fluoride at room temperature afforded smoothly the corresponding 1,4-dihydropyridine monocarboxylic acids (18) in good yields. The monocarboxylic acids 18n and 18o were esterified with 2-nitrooxypropanol or N-(2-hydroxyethyl)nicotinamide p-toluenesulfonic acid salt to afford the selective coronary vasodilators CD-349 (5) and CD-832 (6), respectively.

Synthesis and antihypertensive activities of new 1,4-dihydropyridine derivatives containing a nitrooxy moiety at the 3-ester position

The synthesis of a new series of dihydropyridines containing a nitrooxy moiety at the 3-ester position is described. The antihypertensive activity of the compounds was examined and compared with that of nifedipine; some of them were relatively potent. The structure-activity relationship is also discussed.