53219-40-2

Usage

Type of Compound

Dimethyl ester form of the drug Fipronil

Use

Insecticide and acaricide

Mechanism of Action

Disrupts the central nervous system of insects and pests, causing paralysis and death

Effective Against

Wide range of pests, including ants, cockroaches, termites, and ticks

Characteristics

Highly effective and long-lasting insecticide

Applications

Pest control in agricultural and residential settings

Toxicity

Toxic to birds, fish, and other wildlife; can pose risks to human health with prolonged exposure

Safety Precautions

Important to use with caution and follow all safety guidelines and regulations

InChI:InChI=1/C18H18F3NO4/c1-9-13(16(23)25-3)15(14(10(2)22-9)17(24)26-4)11-7-5-6-8-12(11)18(19,20)21/h5-8,15,22H,1-4H3

Upstream product

• 10230-68-9 1-nitro-2-propanone 
• 447-61-0 2-Trifluoromethylbenzaldehyde 
• 21731-17-9 methyl 3-aminocrotonate 
• 39561-94-9 methyl 2-(2-trifluoromethylphenylmethylene)acetoacetate 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 149143-25-9 dimethyl 1,4-dihydro-2-methyl-6-<(methylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate 
• 120260-20-0 1,3,4,5,7,8-Hexahydro-8-<2-(trifluormethyl)phenyl>-difuro<3,4-b:3',4'-e>pyridin-1,7-dion 
• 85825-31-6 (R,S)-1,4,5,7-Tetrahydro-2-methyl-5-oxo-4-<2-(trifluormethyl)phenyl>furo<3,4-b>pyridin-3-carbonsaeuremethylester 
• 138500-93-3 (R,S)-2-Dibromomethyl-1,4,5,7-tetrahydro-5-oxo-4-<2-(trifluoromethyl)phenyl>-furo-<3,4-b>pyridin-3-carbonsaeuremethylester 
• 130160-96-2 2,6-dimethyl-4-<2-(trifluormethyl)phenyl>-pyridin-3,5-dicarbonsaeuredimethylester 
• 99286-87-0 (2S,3R,4S,5S,6R)-2,6-Dimethyl-4-(2-trifluoromethyl-phenyl)-piperidine-3,5-dicarboxylic acid dimethyl ester 
• 149143-27-1 dimethyl 1,4-dihydro-2-methyl-6,6-bis<(methylthio)methyl>-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate 
• 138486-19-8 5,7-Dihydro-2-methyl-5-oxo-4-<2-(trifluormethyl)phenyl>-furo<3,4-b>pyridin-3-carbonsaeuremethylester 
• 103183-93-3 2-Methyl-5-oxo-4-(2-trifluoromethyl-phenyl)-1,4,5,6-tetrahydro-[1,6]naphthyridine-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

1,4-Dihydropyridine antagonist activities at the calcium channel: A quantitative structure-activity relationship approach

The effect of 46 1,4-dihydropyridine-type calcium channel antagonists on the tonic contractile response of longitudinal muscle strips of guinea pig ileum was determined. 2,6-Dimethyl-3,5-dicarbomethoxy-4-phenyl-1,4-dihydropyridine (13) and 13 ortho-, 15 meta-, and seven para-monosubstituted and 10 polysubstituted aromatic derivatives of 13 were studied. The pharmacological activities of the monosubstituted derivatives were best correlated by eq 10, log 1/C = 0.68π + 2.50σ(m) - 0.47L(meta) - 3.40B1(para) + 11.31, which had a correlation coefficient of 0.89. The full data set was best correlated by eq 11, log 1/C = 0.62π + 1.96σ(m) - 0.44L(meta) - 3.26B1(para) - 1.51L(meta) + 14.23, which had a correlation coefficient of 0.90. Equations of similar form but involving an ortho steric term were found to correlate the radioligand binding data for this class of compounds.