395639-65-3 Usage
Molecular weight
214.61 g/mol The molecular weight is the mass of one mole of the compound and is calculated by adding the atomic weights of all the atoms in the molecule.
Appearance
Colorless liquid The appearance describes the physical form and color of the compound.
Boiling point
110-112°C The boiling point is the temperature at which the compound changes from a liquid to a gas.
Melting point
Not available The melting point is the temperature at which the compound changes from a solid to a liquid. In this case, it is not available because the compound is a liquid at room temperature.
Solubility
Soluble in organic solvents such as ethanol, dichloromethane, and ethyl acetate Solubility describes the ability of the compound to dissolve in different solvents.
Reactivity
The presence of the chloro, fluoro, and iodo substituents gives this chemical compound interesting reactivity. Reactivity describes the compound's ability to undergo chemical reactions with other compounds.
Biological activity
Potential biological activity, making it a valuable molecule for further research and development in the field of medicinal chemistry. Biological activity describes the compound's potential effects on living organisms.
Uses
Commonly used in organic synthesis and pharmaceutical research, and known for its potential applications in the development of new drugs and medicinal compounds. Uses describe the main applications of the compound in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 395639-65-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,9,5,6,3 and 9 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 395639-65:
(8*3)+(7*9)+(6*5)+(5*6)+(4*3)+(3*9)+(2*6)+(1*5)=203
203 % 10 = 3
So 395639-65-3 is a valid CAS Registry Number.
395639-65-3Relevant academic research and scientific papers
Synthesis and preliminary biological characterization of a new potential 125I-radioligand for dopamine and serotonin receptors
Guarna,Menchi,Berti,Cini,Bottoncetti,Raspanti,Politi,Pupi
, p. 3197 - 3206 (2007/10/03)
The synthesis and a preliminary biological characterization of a new class of N-benzyl-aminoalcohols which have serotonin (5-HT2) and dopamine (D2) receptor affinity is described. In vitro competition binding studies were conducted with the new molecules and 3H-spiperone on crude membrane preparation from rat striatum and frontal cortex. One of these compounds, 3-benzylamino-1-(4-fluoro-2-iodophenyl)-propan-1-ol (6f), whose IC50 values are in the micromolar range for both the D2 and 5-HT2 receptors, was prepared in iodine-125 labelled form (6i) by nucleophilic substitution of the bromine atom of 3-benzylamino-1-(2-bromo-4-fluorophenyl)-propan-1-ol (6d). In the in vivo studies, conducted on rats, the radiolabelled molecule 6i shows a good capacity to cross the blood-brain barrier (BBB) with a mean value of first pass cerebral extraction (E) of ca. 50% when the regional cerebral blood flow, measured with microsphere technique, is in the experimental animal's physiologic range (0.8-1 mL/min/g). A preliminary in vitro autoradiographic distribution on coronal rat brain slices of the radioiodinated molecule showed that it was preferentially localized in the striatum and in the cerebral regions rich in dopamine- and serotonin receptors, even if a high non-specific binding was observed.
