39564-96-0

Upstream product

• 70-11-1 α-bromoacetophenone 
• 37891-04-6 2-thioxo-2,3-dihydropyrido/2,3-d/pyrimidin-4(1H)-one 
• 112342-68-4 2-phenacylthiopyrido/2,3-d/pyrimidin-4(3H)-one 
• 2942-59-8 2-chloronicotinic acid 
• 2010-06-2 2-Amino-4-phenylthiazole 

Relevant academic research and scientific papers

TRANSFORMATIONS OF 1,2,4-THIADIAZOLO/2,3-x/AZINES

Hydrolysis of 1,2,4-thiadiazolo/2,3-c/pyrimidine derivative 2 produced cyanoaminopyrimidine 4, while treatment of 1,2,4-thiadiazolo/2,3-b/pyridazine 5 with hydrazine hydrate gave thiourea derivative 7. 1,2,4-Thiadiazolo/2,3-a/pyridine 8 and 1,2,4-thiadiazolo/2,3-a/pyrazine 9 gave by alkaline hydrolysis the corresponding pyridopyrimidine 10 and pteridine 11, respectively.The compound 10 was converted with phenacyl bromide into 14 and further cyclized in PPA into pyrido/2,3-d/thiazolo/2,3-a/pyrimidine 15.Pyrazinylthiourea derivative 16 was cyclized in acidic solution into thiazolo/4,5-b/pyrazine 17, which was converted by hydrolysis and decarboxylation into amino derivative 20.This gave with ethyl acetoacetate pyrazino/2',3':4,5/thiazolo/3,2-a/pyrimidine 23. 1,2,4-Thiadiazoloazines 24 and N-ethoxycarbonyl-N'-azinylthioureas 25 were transformed with hydrogen peroxide into urea derivatives 26.