395683-22-4

Upstream product

• 33155-60-1 t-butyl p-tolylacetate 
• 14062-19-2 p-tolylacetic acid ethyl ester 
• 23786-13-2 methyl p-tolylacetate 
• 35675-44-6 4-methylphenylacetyl chloride 
• 54009-36-8 2-amino-1-(4-(methylsulfonyl)phenyl)ethanone 
• 22535-04-2 p-methylphenylacetyl bromide 
• 657419-48-2 N-n-propyl-N-[2-hydroxy-2-(4'-methylsulfonylphenyl)]ethyl-4-methylphenylacetamide 
• 479679-98-6 N-n-propyl-β-hydroxy-4-methylsulfonylphenylethanamine 
• 93114-06-8 (4-methanesulfonyl-phenyl)-oxirane 

Downstream Products

• 395683-14-4 Imrecoxib 

Relevant academic research and scientific papers

Preparation method of imrecoxib

The invention provides a preparation method of imrecoxib. The preparation method of the imrecoxib comprises the steps that alpha-n-propylamino-4-methyl sulfonate acetophenone (II) and 4-methyl phenylacetate (III) are used as main raw materials, amidation

Preparation methods of imrecoxib intermediate and imrecoxib

The invention discloses preparation methods of an imrecoxib intermediate and imrecoxib. The preparation method of N-propyl-N-[2-oxo-2-(4-mesylphenyl)]ethyl-4-methyl phenyl acetamide as the imrecoxib intermediate comprises the following steps of performing substitution reaction on 2-amino-1-p-methylsulfonyl acetophenone and 1-halopropane in a system of an acid binding agent and a solvent to obtain2-propylamino-1-p-methylsulfonyl acetophenone; and enabling 2-propylamino-1-p-methylsulfonyl acetophenone and p-methyl phenylacetyl halide to perform amidation in the system of the acid binding agentand the solvent to obtain N-propyl-N-[2-oxo-2-(4-mesylphenyl)] ethyl-4-methyl phenyl acetamide. The preparation method of the imrecoxib comprises the following step of performing condensation and cyclization reaction on N-propyl-N-[2-oxo-2-(4-mesylphenyl)] ethyl-4-methyl phenyl acetamide in a system of an alkaline matter and a solvent on the basis. The synthetic route provided by the invention enables the reaction process to be more simple and post-treatment separation to be easier and is capable of acquiring ideal yield.

Preparation method of imrecoxib, and preparation method of imrecoxib intermediate

The invention relates to a preparation method of imrecoxib, and a preparation method of an imrecoxib intermediate. The preparation method of the imrecoxib intermediate remarkably improves the yield ofthe intermediate (III). The preparation method of the imrecoxib is characterized in that p-methylsulfonylstyrene oxide used as an initial raw material undergoes nucleophilic ring opening, acylation,oxidation and cyclization to obtain the final product N-n-propyl-3-(4-methylphenyl)-4-(4-methylsulfonylphenyl)-2,5-dihydropyrrol-2-one. The method has the advantages of short route, simplicity in operation, and suitableness for industrial amplified production.

Sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones, preparation method, and medical use thereof

The invention relates to sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones compounds having formula (I) wherein R1 is selected from the group consisting of 4-methylsulfonyl, 4-aminosulfonyl, hydrogen, 2-, 3-, or 4-halogen, C1-C6