657419-48-2

Upstream product

• 479679-98-6 N-n-propyl-β-hydroxy-4-methylsulfonylphenylethanamine 
• 35675-44-6 4-methylphenylacetyl chloride 
• 93114-06-8 (4-methanesulfonyl-phenyl)-oxirane 

Downstream Products

• 395683-22-4 N-n-propyl-N-[2-oxo-2-(4'-methylsulfonylphenyl)]ethyl-4-methylphenylacetamide 

Relevant academic research and scientific papers

Preparation method of imrecoxib, and preparation method of imrecoxib intermediate

The invention relates to a preparation method of imrecoxib, and a preparation method of an imrecoxib intermediate. The preparation method of the imrecoxib intermediate remarkably improves the yield ofthe intermediate (III). The preparation method of the imrecoxib is characterized in that p-methylsulfonylstyrene oxide used as an initial raw material undergoes nucleophilic ring opening, acylation,oxidation and cyclization to obtain the final product N-n-propyl-3-(4-methylphenyl)-4-(4-methylsulfonylphenyl)-2,5-dihydropyrrol-2-one. The method has the advantages of short route, simplicity in operation, and suitableness for industrial amplified production.

Sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones, preparation method, and medical use thereof

The invention relates to sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones compounds having formula (I) wherein R1 is selected from the group consisting of 4-methylsulfonyl, 4-aminosulfonyl, hydrogen, 2-, 3-, or 4-halogen, C1-C6