39575-23-0Relevant academic research and scientific papers
Synthesis, Structural Characterization, and Biological Evaluation of Some Hydrazone Compounds as Potential Antioxidant Agents
??nar, Ercan,?akmak, Re?it,Eyup, Basaran,Ha?imi, Nesrin
, p. 143 - 152 (2022/03/17)
Abstract: Antioxidants are sufficiently stable molecules that neutralize free radicals by electron transfer and thereby reduce their damaging capacity. Hydrazones, which are frequently used in the discovery studies of new antioxidant agents, are bioactive compounds with very significant utilization areas because of their various biological and clinical applications. In this study, in vitro antioxidant activities of the previously synthesized hydrazone compounds against various free radicals were examined, one by one. It was determined that among the synthesized compounds (II–VIII), especially the compound (II) had a significant effect (IC50 = 4.4 ± 0.04 μg/mL for DPPH, IC50 = 1.8 ± 0.07 μg/mL for ABTS and A0.5 = 2.2 ± 0.02 μg/mL for CUPRAC) on the prevention of free radical-induced oxidative stress, as better results were obtained than the standard substance. All synthesized compounds showed good antioxidant effects compared to BHA in the CUPRAC method. The obtained results demonstrate that most of the synthesized molecules are promising antioxidant agents.
Benzylidene/2-chlorobenzylidene hydrazides: Synthesis, antimicrobial activity, QSAR studies and antiviral evaluation
Kumar, Davinder,Judge, Vikramjeet,Narang, Rakesh,Sangwan, Sonia,De Clercq, Erik,Balzarini, Jan,Narasimhan, Balasubramanian
experimental part, p. 2806 - 2816 (2010/08/20)
A series of benzylidene hydrazides (1-20) was synthesized and tested, in vitro, for antibacterial, antifungal and antiviral activities. The microbial screening results indicated that compounds having chloro and nitro substituents were the most active ones. The antiviral evaluation depicted that compounds 9 and 19 were active against Vesicular stomatitis virus (VSV) in HeLa cell cultures. QSAR investigations indicated that the multi-target QSAR model was effective in describing the antimicrobial (antibacterial and antifungal) activity over the one-target QSAR models. Further the mt-QSAR model indicated that the topological parameters, second order molecular connectivity index (2χ) and third order Kier's alpha shape index (κα3) are effective in describing the antimicrobial activity of synthesized hydrazides.
Synthesis and spectral studies of some magnesium complexes of aromatic hydrazones
Adeniyi,Oyedeji,Aremu,Okedeyi,Bourne
, p. 246 - 250 (2008/02/02)
Six esters were synthesized from their parent acids, while their corresponding hydrazides were subsequently synthesized from these esters. The hydrazides, on reaction with benzaldehyde, produced their respective hydrazones, namely, benzoic hydrazone (BH),
