39581-63-0

Usage

Uses

Used in Rubber, Plastics, and Polymers Industry:
2,4,5,8-Tetramethylquinoline is used as a stabilizer and antioxidant for the production of rubber, plastics, and polymers. It helps to prevent degradation and maintain the integrity of these materials, thereby extending their lifespan and performance.
Used in Pharmaceutical Industry:
2,4,5,8-Tetramethylquinoline is used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. Its unique chemical structure allows it to be a key component in the development of new drugs and medications.
Safety Precautions:
It is important to handle 2,4,5,8-Tetramethylquinoline with care, as it can cause skin and eye irritation. Additionally, it may be harmful if ingested or inhaled, so proper safety measures should be taken during its use and storage.

InChI:InChI=1/C13H15N/c1-8-5-6-9(2)13-12(8)10(3)7-11(4)14-13/h5-7H,1-4H3

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Relevant academic research and scientific papers

Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase

Nicotinamide N-methyltransferase (NNMT) is a fundamental cytosolic biotransforming enzyme that catalyzes the N-methylation of endogenous and exogenous xenobiotics. We have identified small molecule inhibitors of NNMT with >1000-fold range of activity and developed comprehensive structure-Activity relationships (SARs) for NNMT inhibitors. Screening of N-methylated quinolinium, isoquinolinium, pyrididium, and benzimidazolium/benzothiazolium analogues resulted in the identification of quinoliniums as a promising scaffold with very low micromolar (IC50 à 1 μM) NNMT inhibition. Computer-based docking of inhibitors to the NNMT substrate (nicotinamide)-binding site produced a robust correlation between ligand-enzyme interaction docking scores and experimentally calculated IC50 values. Predicted binding orientation of the quinolinium analogues revealed selective binding to the NNMT substrate-binding site residues and essential chemical features driving protein-ligand intermolecular interactions and NNMT inhibition. The development of this new series of small molecule NNMT inhibitors direct the future design of lead drug-like inhibitors to treat several metabolic and chronic disease conditions characterized by abnormal NNMT activity.

8-Methylquinoline palladacycles: Stable and efficient catalysts for carbon-carbon bond formation

Cyclopalladated, phosphine free, 8-methyl quinoline based complexes (2a-j) are excellent catalysts for the Heck vinylation of aryl iodides and bromides with turnover numbers of greater than 25 million observed in some cases. The catalysts are air and moisture stable.