39585-75-6

Usage

Uses

Used in Organic Synthesis:
(1-oxidopyridin-2-yl)(phenyl)methanol is used as a building block for the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. Its structural features make it a valuable component in the synthesis of complex organic compounds.
Used in Medicinal Chemistry and Drug Discovery:
Due to its pharmacological properties and structural features, (1-oxidopyridin-2-yl)(phenyl)methanol has potential applications in the field of medicinal chemistry and drug discovery. It can contribute to the development of new drugs and therapeutic agents.
Used in the Synthesis of Complex Organic Compounds:
(1-oxidopyridin-2-yl)(phenyl)methanol can serve as a starting material for the synthesis of more complex organic compounds with diverse biological activities. This makes it a valuable resource in the creation of innovative chemical entities for various applications.

Upstream product

• 49836-04-6 ortho-iodopyridine N-oxide 
• 100-52-7 benzaldehyde 
• 694-59-7 pyridine N-oxide 
• 120809-70-3 2-(phenyltrimethylsiloxymethyl)-pyridine 1-oxide 
• 120809-69-0 trimethylsilyl-2-pyridinecarboxylate-1-oxide 
• 51148-07-3 Na salt of 2-pyridinecarboxylic acid 1-oxide 
• 824-40-8 2-pyridinecarboxylic acid N-oxide 

Relevant academic research and scientific papers

Magnesiation of pyridine N-oxides via iodine or bromine-magnesium exchange: A useful tool for functionalizing pyridine N-oxides

Iodo- or 2-bromopyridine N-oxides were readily magnesiated with i-PrMgCl ? LiCl via the iodine or bromine-magnesium exchange. The bromine adjacent to pyridine N-oxide (at the 2- or 6-position) can be regioselectively magnesiated in the presence of other position substituted halogens. This method was tested in various substituted pyridine N-oxide systems, and has been successfully applied to the total synthesis of caerulomycins E and A.

ELECTROPHILIC REACTION OF PYRIDINE, QUINOLINE, ISOQUINOLINE, THEIR N-OXIDES AND THEIR BORON TRIFLUORIDE COMPLEXES THROUGH BASE-INDUCED DEPROTONATION

The comparative studies have been carried out on reactivities of pyridine, quinoline, isoquinoline, and their BF3 complexes, their N-oxides, and their N-oxide-BF3-complexes, towards the electrophilic reaction through α-deprotonation.

IPSO SUBSTITUTION OF HETEROCYCLIC TRIMETHYLSILYL CARBOXYLATES BY CARBON ELECTROPHILES

Trimethylsilyl esters 1 of heterocyclic carboxylic acids having the ester group in the α-position to an azine nitrogen atom react with aldehydes or ketones through ipso substitution of the ester group to give (trimethylsiloxy)-alkyl-substituted heterocyclic products in good yields.