396072-77-8

Basic information

• Product Name: 4-{[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butylamino]-methyl}-piperidine-1-carboxylic acid benzyl ester
• CAS NO: 396072-77-8
• Molecular Weight: 449.55
• Mol File: 396072-77-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-{[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butylamino]-methyl}-piperidine-1-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butylamino]-methyl}-piperidine-1-carboxylic acid benzyl ester(396072-77-8)
• EPA Substance Registry System: 4-{[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butylamino]-methyl}-piperidine-1-carboxylic acid benzyl ester(396072-77-8)

Safety Data

• Hazardous Substances Data: 396072-77-8(Hazardous Substances Data)

Upstream product

• 5394-18-3 2-(4-bromobutyl)isoindoline-1,3-dione 
• 157023-34-2 4-aminomethyl-piperidine-1-carboxylic acid benzyl ester 
• 7144-05-0 4-Aminomethylpiperidine 
• 396072-76-7 N-(1-benzyloxycarbonylpiperidin-4-ylmethyl)phthalimide 

Downstream Products

• 396072-80-3 4-({tert-butoxycarbonyl-[4-(tert-butoxycarbonyl-cyclohexylmethyl-amino)-butyl]-amino}-methyl)-piperidine-1-carboxylic acid benzyl ester 
• 396072-81-4 N,N'-bis(tert-butoxylcarbonyl)-N-cyclohexylmethyl-N'-(piperidin-4-ylmethyl)-1,4-diaminobutane 
• 396072-79-0 4-[N-(4-aminobutyl)-N-tert-butoxylcarbonylaminomethyl]-1-benzyloxycarbonylpiperidine 
• 396072-78-9 4-({tert-butoxycarbonyl-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-amino}-methyl)-piperidine-1-carboxylic acid benzyl ester 

Relevant articles and documents

Discovery of diaminobutane derivatives as Ca(2+)-permeable AMPA receptor antagonists.

We designed and synthesized a series of the polyamine derivatives as potent Ca(2+)-permeable AMPA receptor antagonists. In the course of this study, we found that the polyamine derivatives exhibited strong hypotensive activity which was undesirable activity for neuroprotective agents. Therefore, we tried to find non-hypotensive antagonists by structural modification of such compounds. Through this derivatization, we obtained the diamine compounds having desired profiles. Especially, compound 8f, which was non-hypotensive and potent Ca(2+)-permeable AMPA receptor antagonist, showed neuroprotective effects in transient global ischemia models in gerbils.