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Pleurosine is a complex alkaloid found in the plant Vinca rosea L. It is one of the Vinca alkaloids and can be purified through recrystallization from methanol, resulting in colorless blades. Pleurosine exhibits a leavorotatory optical rotation with a specific rotation of -61° (c 1.0, CHCl3) and has an ultraviolet spectrum with two absorption maxima at 267 and 308 nm. Its molecular structure is that of leurosine Nb-oxide.

39608-80-5

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39608-80-5 Usage

Uses

1. Used in Pharmaceutical Industry:
Pleurosine is used as a chemotherapeutic agent for the treatment of various types of cancer. It works by inhibiting microtubule assembly, which leads to the disruption of cell division and ultimately results in cell death. Pleurosine is particularly effective against solid malignancies such as breast, lung, and ovarian cancers.
2. Used in Drug Delivery Systems:
To enhance the efficacy and bioavailability of pleurosine, researchers have developed novel drug delivery systems. These systems utilize various organic and metallic nanoparticles as carriers for pleurosine, aiming to improve its delivery to cancer cells and overall therapeutic outcomes.
3. Used in Research and Development:
Pleurosine serves as an important compound for scientific research, particularly in the fields of cancer biology and pharmacology. Its unique structure and properties make it a valuable tool for understanding the mechanisms of action of various chemotherapeutic agents and for the development of new cancer treatments.

References

Svoboda ct al., 1. Pharrn. Sci., 51, 518 (1962)

Check Digit Verification of cas no

The CAS Registry Mumber 39608-80-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,9,6,0 and 8 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 39608-80:
(7*3)+(6*9)+(5*6)+(4*0)+(3*8)+(2*8)+(1*0)=145
145 % 10 = 5
So 39608-80-5 is a valid CAS Registry Number.
InChI:InChI=1/C46H56N4O10/c1-8-42-16-12-18-49-19-17-44(38(42)49)31-21-32(35(56-6)22-34(31)48(5)39(44)46(54,41(53)57-7)40(42)58-26(3)51)45(59-27(4)52)23-28-24-50(55,25-43(9-2)37(28)60-43)20-15-30-29-13-10-11-14-33(29)47-36(30)45/h10-14,16,21-22,28,37-40,47,54H,8-9,15,17-20,23-25H2,1-7H3

39608-80-5Upstream product

39608-80-5Downstream Products

39608-80-5Relevant academic research and scientific papers

COMPOSES ANTITUMORAUX DU GROUPE DE LA VINBLASTINE: NOUVELLE METHODE DE PREPARATION

Andriamialisoa, R. Z.,Langlois, N.,Langlois, Y.,Potier, P.

, p. 3053 - 3060 (1980)

7'-Chloro-indolenines from several dimeric alkaloids of vinblastine type are useful intermediates in the preparation of antitumor derivatives belonging to seco-5',6' and nor-5'series.

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