23360-92-1 Usage
Description
Vinqa rosea yields this complex dimeric alkaloid which forms colourless crystals
that are best purified by recrystallization from acetonitrile. It crystallizes with 8
moles of H20 and loses solvent when heated at In-5°C. It is also dextro?
rotatory with [α]26D + n° (CHCI3)’ A crystalline SUlphate is known which has
m.p. 238-242°C (dec.) and [α]D - 8.3° (MeOH). The N(b)-oxide is identical
with pleurosine (q.v.).
Uses
Different sources of media describe the Uses of 23360-92-1 differently. You can refer to the following data:
1. Vinleurosine is an antitumor compound derived from Vinca Rosea.
2. Antineoplastic.
References
Svoboda., J. Amer. Pharm. Assoc., 47,834 (1959)
Neuss et al., J. Amer. Chern. Soc., 81,4754 (1959)
Revised structure:
Neuss et al., Tetrahedron Lett., 783 (1968)
Check Digit Verification of cas no
The CAS Registry Mumber 23360-92-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,3,6 and 0 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 23360-92:
(7*2)+(6*3)+(5*3)+(4*6)+(3*0)+(2*9)+(1*2)=91
91 % 10 = 1
So 23360-92-1 is a valid CAS Registry Number.
InChI:InChI=1/C46H56N4O9/c1-8-42-16-12-18-50-20-17-44(37(42)50)30-21-31(34(55-5)22-33(30)48(4)38(44)46(54,41(53)57-7)39(42)58-26(3)51)45(40(52)56-6)23-27-24-49(25-43(9-2)36(27)59-43)19-15-29-28-13-10-11-14-32(28)47-35(29)45/h10-14,16,21-22,27,36-39,47,54H,8-9,15,17-20,23-25H2,1-7H3/t27-,36-,37+,38-,39-,42-,43+,44-,45+,46+/m1/s1
23360-92-1Relevant articles and documents
Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature
Asano, Mamiko,Harada, Kazuo,Yoshikawa, Tomoaki,Bamba, Takeshi,Hirata, Kazumasa
body text, p. 386 - 389 (2010/10/03)
We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near- ultraviolet light irradiation in vitro. The present study found that the concentrations of cath
ALKALOID PRODUCTION IN CATHARANTHUS ROSEUS (L.) G. DON CELL CULTURES, XV. SYNTHESIS OF BISINDOLE ALKALOIDS BY USE OF IMMOBILIZED ENZYME SYSTEMS
Kutney, James Peter,Boulet, Camille Andre,Choi, Lewis Siu Leung,Gustowski, Wlodzimierz,McHugh, Michael,et al.
, p. 621 - 628 (2007/10/02)
Affinity gel bound enzyme systems obtained from Catharanthus roseus cell cultures were employed to establish a high yielding enzymatic system for the coupling of catharanthine (1) and vindoline (2) to 3',4'-anhydrovinblastine (3) and leurosine (4).Long term enzymatic activity can be preserved by this technique, an aspect which may prove important in subsequent utilization of such systems in large scale production.
Biosynthesis of the indole alkaloids. Cell-free systems from Catharanthus roseus plants
Kutney,Choi,Honda,et al.
, p. 2088 - 2101 (2007/10/02)
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