396090-41-8

Upstream product

• 108-24-7 acetic anhydride 
• 396090-23-6 Fmoc-Phe-1,2-dihydro-3(6H)-pyridinyl-Leu-Ach-Ile tert-butyl ester 
• 396090-22-5 Alloc-Ach-Leu-1,2-dihydro-3(6H)-pyridinyl-Ile tert-butyl ester 
• 396090-40-7 Ach-Leu-Ach-Ile tert-butyl ester 
• 396090-19-0 tert-butyl (2S,3S)-3-methyl-2-{[5-oxo-1-(prop-2-enyloxycarbonyl)-1,2,6-trihydro-3-pyridyl]amino}pentanoate 
• 396090-18-9 prop-2-enyl 3-oxo-5-[(2,4,6-trimethylphenyl)sulfonyloxy]-1,2,6-trihydropyridine-1-carboxylate 
• 396090-34-9 tert-butyl (2S)-4-methyl-2-{[5-oxo-1-(prop-2-enyloxycarbonyl)-1,2,6-trihydro-3-pyridyl]amino}pentanoate 
• 396090-21-4 (2S)-4-methyl-2-[[5-oxo-1-(prop-2-enyloxycarbonyl)-1,2,6-trihydro-3-pyridyl]amino]pentanoic acid 
• 396090-43-0 tert-butyl (2S,3S)-3-methyl-2-[(5-oxo-1,2,6-trihydro-3-pyridyl)amino]pentanoate 
• 871503-96-7 3,5-dimethoxy-2H-pyridine-1-carboxylic acid allyl ester 
• 396090-17-8 prop-2-enyl 5-hydroxy-3-oxo-1,2,6-trihydropyridine-1-carboxylate 
• 2457-47-8 3,5-dichloropyridine 
• 18677-48-0 3,5-dimethoxypyridine 

Downstream Products

• 396090-42-9 Ac-Phe-Ach-Leu-Ach-Ile 

Relevant academic research and scientific papers

"@-Tides": The 1,2-dihydro-3(6h)-pyridinone unit as a β-strand mimic

The cyclic amino acid surrogate 1 was designed to mimic the extended conformation of a peptide unit and to provide hydrogen bond donor and acceptor functions conducive to β-sheet formation. A convenient synthesis of this unit and solution and solid-phase methods for its incorporation into an oligomer alternating with peptide units have been devised. The resulting "@-tides", as these oligomers have been designated, show a high propensity for self-association in comparison to oligopeptides; insights into the structure and dynamical properties of their antiparallel dimers have been obtained by NMR.