396090-18-9

Upstream product

• 773-64-8 2-mesitylenesulphonyl chloride 
• 396090-17-8 prop-2-enyl 5-hydroxy-3-oxo-1,2,6-trihydropyridine-1-carboxylate 
• 18677-48-0 3,5-dimethoxypyridine 
• 871503-96-7 3,5-dimethoxy-2H-pyridine-1-carboxylic acid allyl ester 
• 2457-47-8 3,5-dichloropyridine 

Downstream Products

• 396090-23-6 Fmoc-Phe-1,2-dihydro-3(6H)-pyridinyl-Leu-Ach-Ile tert-butyl ester 
• 396090-41-8 Ac-Phe-Ach-Leu-Ach-Ile tert-butyl ester 
• 396090-42-9 Ac-Phe-Ach-Leu-Ach-Ile 
• 396090-39-4 Ach-Phe t-butyl ester 
• 396090-35-0 tert-butyl (2S)-2-{[5-oxo-1-(prop-2-enyloxycarbonyl)-1,2,6-trihydro-3-pyridyl]amino}-3-phenylpropanoate 

Relevant academic research and scientific papers

"@-Tides": The 1,2-dihydro-3(6h)-pyridinone unit as a β-strand mimic

The cyclic amino acid surrogate 1 was designed to mimic the extended conformation of a peptide unit and to provide hydrogen bond donor and acceptor functions conducive to β-sheet formation. A convenient synthesis of this unit and solution and solid-phase methods for its incorporation into an oligomer alternating with peptide units have been devised. The resulting "@-tides", as these oligomers have been designated, show a high propensity for self-association in comparison to oligopeptides; insights into the structure and dynamical properties of their antiparallel dimers have been obtained by NMR.