396092-84-5

Basic information

• Product Name: 4-N,N-Dimethylamino-2-(tributylstannyl)-pyridine
• Synonyms: 4-N,N-Dimethylamino-2-(tributylstannyl)-pyridine;N,N-dimethyl-2-(tributylstannyl)-4-Pyridinamine
• CAS NO: 396092-84-5
• Molecular Formula: C₁₉H₃₆N₂Sn
• Molecular Weight: 411.21
• Mol File: 396092-84-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-N,N-Dimethylamino-2-(tributylstannyl)-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-N,N-Dimethylamino-2-(tributylstannyl)-pyridine(396092-84-5)
• EPA Substance Registry System: 4-N,N-Dimethylamino-2-(tributylstannyl)-pyridine(396092-84-5)

Safety Data

• Hazardous Substances Data: 396092-84-5(Hazardous Substances Data)

Usage

General Description

4-N,N-Dimethylamino-2-(tributylstannyl)-pyridine is a chemical compound that contains a pyridine ring with a dimethylamino group and a tributylstannyl group attached to it. It is commonly used as a reagent in organic synthesis, particularly in the preparation of functionalized pyridines and other heterocyclic compounds. The tributylstannyl group can act as a leaving group in various reactions, and the dimethylamino group can participate in nucleophilic substitution or coordination with metal catalysts. 4-N,N-Dimethylamino-2-(tributylstannyl)-pyridine has found applications in the synthesis of pharmaceuticals, agrochemicals, and materials science, making it a valuable tool for chemists working in these fields. However, it is important to handle and dispose of this compound properly, as tributylstannyl compounds are known to be toxic and pose a risk to the environment.

Upstream product

• 1122-58-3 dmap 
• 1461-22-9 tributyltin chloride 

Downstream Products

• 457644-71-2 4-(N,N-dimethylamino)-2-(2,4-dinitrophenyl)pyridine 
• 85698-56-2 N⁴,N⁴,N^4',N^4'-tetramethyl-[2,2'-bipyridine]-4,4'-diamine 
• 1053216-42-4 4-(N,N-dimethylamino)-2-(2-nitrophenyl)pyridine 
• 457644-76-7 N-[5-acetylamino-2-(4-dimethylamino-pyridin-2-yl)-phenyl]-2,2-dimethyl-propionamide 
• 457644-75-6 N-[5-amino-2-(4-dimethylamino-pyridin-2-yl)-phenyl]-2,2-dimethyl-propionamide 
• 457644-69-8 2-(2,4-diaminophenyl)-4-(N,N-dimethylamino)pyridine 

Relevant articles and documents

Strategic Design of 2,2′-Bipyridine Derivatives to Modulate Metal-Amyloid-β Aggregation

The complexity of Alzheimer’s disease (AD) stems from the inter-relation of multiple pathological factors upon initiation and progression of the disease. To identify the involvement of metal-bound amyloid-β (metal-Aβ) aggregation in AD pathology, among the pathogenic features found in the AD-affected brain, small molecules as chemical tools capable of controlling metal-Aβ aggregation were developed. Herein, we report a new class of 2,2′-bipyridine (bpy) derivatives (1-4) rationally designed to be chemical modulators toward metal-Aβ aggregation over metal-free Aβ analogue. The bpy derivatives were constructed through a rational design strategy employing straightforward structural variations onto the backbone of a metal chelator, bpy: (i) incorporation of an Aβ interacting moiety; (ii) introduction of a methyl group at different positions. The newly prepared bpy derivatives were observed to bind to metal ions [i.e., Cu(II) and Zn(II)] and interact with metal-Aβ over metal-free Aβ to varying degrees. Distinguishable from bpy, the bpy derivatives (1-3) were indicated to noticeably modulate the aggregation pathways of Cu(II)-Aβ and Zn(II)-Aβ over metal-free Aβ. Overall, our studies of the bpy derivatives demonstrate that the alteration of metal binding properties as well as the installation of an Aβ interacting capability onto a metal chelating framework, devised via the rational structure-based design, were able to achieve evident modulating reactivity against metal-Aβ aggregation. Obviating the need for complicated structures, our design approach, presented in this work, could be appropriately utilized for inventing small molecules as chemical tools for studying desired metal-related targets in biological systems.

CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS

The subject matter described herein is directed to ferroportin inhibitor compounds of Formula I or I' and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries.

Ru(II) complexes of tetradentate ligands related to 2,9-Di(pyrid-2′- yl)-1,10-phenanthroline

A series of 1,10-phenanthrolines were prepared having additional ligating substituents at the 2,9-positions. These substituents were either a 4-substituted pyrid-2-yl, quinolin-2-yl, 1,8-naphthyrid-2-yl, N-methyl imidazo-2-yl, or N-methyl benzimidazo-2-yl group. Additionally, 3,6-di-(pyrid-2′-yl)-dipyrido[3,2-a:2′,3′-c]phenazine was prepared. All but two of these ligands coordinated Ru(II) in a tetradentate equatorial fashion with two 4-methylpyridines bound in the axial sites. An X-ray structure analysis of the diimidazoyl system indicates considerable distortion from square planar geometry in the equatorial plane. Previously reported variations in the axial ligand for such complexes appear to have a stronger effect on the electronic absorption and redox properties of the system than similar changes in the equatorial ligand. In the presence of excess Ce(IV) as a sacrificial oxidant at pH 1, all the systems examined catalyze the decomposition of water to generate oxygen. Turnover numbers are modest, ranging from 146 to 416.