39616-95-0

Usage

Uses

Used in Pharmaceutical Research:
4-Fluoro-2-nitrophenylacetic acid is utilized as a key intermediate in the synthesis of various pharmaceutical compounds due to its unique structure and reactivity. Its presence in the molecular framework can influence the pharmacokinetics and pharmacodynamics of the resulting drugs, making it a valuable component in drug design.
Used in Organic Synthesis:
As a building block in organic synthesis, 4-Fluoro-2-nitrophenylacetic acid is employed for the preparation of a range of organic compounds. Its fluorinated and nitro-substituted aromatic ring allows for versatile synthetic pathways, facilitating the creation of complex organic molecules for various applications.
Used in Biological and Pharmacological Studies:
4-Fluoro-2-nitrophenylacetic acid serves as a probe in biological and pharmacological research, helping scientists to investigate molecular mechanisms and drug interactions. Its potential as an anti-inflammatory and analgesic agent is of particular interest, as it may contribute to the development of new therapeutics for pain management and inflammation control.
Used in Drug Development:
4-Fluoro-2-nitrophenylacetic acid is used as a starting material in the development of new drugs. Its unique chemical properties can lead to the discovery of novel therapeutic agents with improved efficacy and safety profiles, particularly in the areas of inflammation and pain management.

Upstream product

• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 147124-35-4 dimethyl 2-(4-fluoro-2-nitrophenyl)malonate 
• 446-10-6 2-nitro-4-fluorotoluene 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 70931-83-8 <4-Fluoro-2-(4-nitrophenylthio)phenyl>acetic acid 
• 56341-39-0 6-fluoro-2-oxindole 
• 80733-63-7 (2-Amino-4-fluoro-phenyl)-acetic acid 

Relevant academic research and scientific papers

Design, synthesis, and SAR of new pyrrole-oxindole progesterone receptor modulators leading to 5-(7-fluoro-3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)- 1-methyl-1H-pyrrole-2-carbonitrile (WAY-255348)

We have continued to explore the 3,3-dialkyl-5-aryloxindole series of progesterone receptor (PR) modulators looking for new agents to be used in female healthcare: contraception, fibroids, endometriosis, and certain breast cancers. Previously we reported

Indoline derivatives substituted in the 6 position, their preparation and their use as medicaments

The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula in which R1 to R6 and X are as defined in claim 1, to their tautomers, enantiomers, diastereomers, to their mixtures and to their

Phenylaminopropanol derivatives and methods of their use

The present invention is directed to phenylaminopropanol derivatives of formula I: or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

HETEROCYCLICALLY SUBSTITUTED INDOLINONES, THEIR PRODUCTION AND USE AS MEDICAMENTS

The invention relates to heterocyclically substituted indolinones of general formula (I), in which R1 to R5 and X are defined as cited in claim 1, to their tautomers, diastereomers, enantiomers and to their mixtures, prodrugs and salts, in particular their physiologically compatible salts. Said compounds exhibit valuable pharmacological characteristics, in particular an inhibiting action on various receptor tyrosine kinases and cyclin-CDK complexes and on the proliferation of endothelial cells and various tumour cells. The invention also relates to medicaments containing said compounds, to the use of the latter and to a method for producing the same.

3-heteroarylidene-2-indolinone protein kinase inhibitors

The present invention relates to novel 3-heteroarylidene-2-indolinone compounds and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

3-(cycloalkanoheteroarylidenyl)-2-indolinone protein tyrosine kinase inhibitors

The present invention relates to novel 3-(cycloalkano-heteroarylidenyl)-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which are expected to modulate the activity of protein tyrosine kinases and therefore to be useful in the prevention and treatment of protein tyrosine kinase related cellular disorders such as cancer.

3-(cycloalkanoheteroarylidenyl)-2- indolinone protein tyrosine kinase inhibitors

The present invention relates to novel 3-(cycloalkanoheteroarylidenyl)-2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which are expected to modulate the activity of protein tyrosine kinases and therefore to be useful in the prevention and treatment of protein tyrosine kinase related cellular disorders such as cancer.