39619-69-7

Basic information

• Product Name: N-HEXYLTETRAOXYETHYLENE
• Synonyms: TETRAETHYLENEGLYCOLMONOHEXYL ETHER;N-HEXYLTETRAOXYETHYLENE;C6E4;C6E4, TetraethyleneglycolMonohexylether
• CAS NO: 39619-69-7
• Molecular Formula: C14H30O5
• Molecular Weight: 278.39
• Mol File: 39619-69-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 365.509°C at 760 mmHg
• Flash Point: 174.854°C
• Appearance: /
• Density: 0.985g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.446
• Storage Temp.: -15°C
• CAS DataBase Reference: N-HEXYLTETRAOXYETHYLENE(CAS DataBase Reference)
• NIST Chemistry Reference: N-HEXYLTETRAOXYETHYLENE(39619-69-7)
• EPA Substance Registry System: N-HEXYLTETRAOXYETHYLENE(39619-69-7)

Safety Data

• Hazardous Substances Data: 39619-69-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H30O5/c1-2-3-4-5-7-16-9-11-18-13-14-19-12-10-17-8-6-15/h15H,2-14H2,1H3

Upstream product

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Relevant articles and documents

Combinatorial synthesis of PEG oligomer libraries

A simple chain-extending approach was established for the scale-up of the monoprotected monodisperse PEG diol materials. Reactions of THP-(OCH2CH2)n—OMs (n=4, 8, 12) with a large excess of commercially available H—(OCH2CH2)n—OH (n=1-4) under basic conditions led to THP-(OCH2CH2)n—OH (n=5-15). Similarly, Me-(OCH2CH2)n—OH (n=4-11, 13) were prepared from Me-(OCH2CH2)n—OMs (n=3, 7, 11). For the chain elongation steps, 40-80% yields were achieved through extraction purification. PEG oligomer libraries I and II were generated in 50-95% overall yields by alkylation or acylation of THP-(OCH2CH2)n—OH (n=1-15) followed by deprotection. Alkylation of Me-(OCH2CH2)n—OH (n=1-11, 13) with X—(CH2)m—CO2R (X=Br or OMs) and subsequent hydrolysis led to PEG oligomer library III in 30-60% overall yields. Combinatorial purification techniques were adapted to the larger-scale library synthesis. A total of 498 compounds, each with a weight of 2-5 g and a minimum purity of 90%, were synthesized.