39623-53-5Relevant academic research and scientific papers
REACTION OF o-PHENYLENEDIAMINE WITH ACETOACETIC AND α-CHLOROACETOACETIC ESTERS
Sheremet, V.I.,Dryuk, V. G.,Solomko, Z. F.,Kremlev, M. M.
, p. 941 - 945 (1981)
The reactivities of acetoacetic and α-chloroacetoacetic esters in the reaction with o-phenylenediamine are compared.In contrast to the available data, it was established that in polyphosphoric acid(PPA) acetoacetic esters is converted to 4-methyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one and ethyl 3-(2-aminoanilino)-crotonate, while chloroacetoacetic esters is converted to 2-methylbenzimidazole.At 20 deg C chloroacetoacetic esters is converted to ethyl 2-chloro-3-(2-amino-anilino)crotonate.The conversion of this ester to 2-methyl-3-ethoxy-2,3-dihydro-1H-1,5-benzodiazepin-2-one was studied.
A Short Synthetic Route to 4,7-Dihalogenated 1,10-Phenanthrolines with Additional Groups in 3,8-Position: Soluble Precursors for Macrocyclic Oligophenanthrolines
Schmittel, Michael,Ammon, Horst
, p. 785 - 792 (2007/10/03)
A short and efficient preparation of 3,8-dialkylated or 3,8-diarylated 1,10-phenanthrolines-4,7-diones is described. Their chlorination or bromination furnishes the corresponding, highly soluble 4,7-dichloro- or 4,7-dibromo phenanthrolines that constitute versatile precursors to macrocyclic oligophenanthrolines with exo-coordination sites. They can be further reacted by nucleophilic aromatic substitution or Heck-coupling reactions.
BENTONITE K10 CLAY, AN EFFICIENT CATALYST FOR THE FORMATION OF NITROGEN DERIVATIVES
Eynde, Jean Jacques Vanden,Mayence, Annie,Lor, Pascal,Haverbeke, Yves Van
, p. 387 - 392 (2007/10/02)
Bentonite K10 clay has been used to catalyze the formation of enamino carbonyl derivatives, 2-methyl-1H-benzimidazoles, Hantzsch 1,4-dihydropyridines, Hantzsch pyridines, 2-substituted 1,3-diphenylimidazolidines, and tetrahydropyranylbenzazoles.
Substituted 1,5-benzodiazepine compounds
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, (2008/06/13)
Compounds of the formula STR1 wherein R1 is alkyl, alkenyl, alkynyl, cycloalkyl, or substituted alkyl, and R4 is aryl or heterocyclo are disclosed. These compounds are useful as cardiovascular agents and especially as anti-hypertensi
