Chemistry of Heterocyclic Compounds p. 941 - 945 (1981)
Update date:2022-07-30
Topics:
Sheremet, V.I.
Dryuk, V. G.
Solomko, Z. F.
Kremlev, M. M.
The reactivities of acetoacetic and α-chloroacetoacetic esters in the reaction with o-phenylenediamine are compared.In contrast to the available data, it was established that in polyphosphoric acid(PPA) acetoacetic esters is converted to 4-methyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one and ethyl 3-(2-aminoanilino)-crotonate, while chloroacetoacetic esters is converted to 2-methylbenzimidazole.At 20 deg C chloroacetoacetic esters is converted to ethyl 2-chloro-3-(2-amino-anilino)crotonate.The conversion of this ester to 2-methyl-3-ethoxy-2,3-dihydro-1H-1,5-benzodiazepin-2-one was studied.
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