Chemistry of Heterocyclic Compounds p. 941 - 945 (1981)
Update date:2022-07-30
Topics:
Sheremet, V.I.
Dryuk, V. G.
Solomko, Z. F.
Kremlev, M. M.
The reactivities of acetoacetic and α-chloroacetoacetic esters in the reaction with o-phenylenediamine are compared.In contrast to the available data, it was established that in polyphosphoric acid(PPA) acetoacetic esters is converted to 4-methyl-2,3-dihydro-1H-1,5-benzodiazepin-2-one and ethyl 3-(2-aminoanilino)-crotonate, while chloroacetoacetic esters is converted to 2-methylbenzimidazole.At 20 deg C chloroacetoacetic esters is converted to ethyl 2-chloro-3-(2-amino-anilino)crotonate.The conversion of this ester to 2-methyl-3-ethoxy-2,3-dihydro-1H-1,5-benzodiazepin-2-one was studied.
View MoreContact:0086-29-89196322
Address:North of the Fifth Keji Road, Hi-Tech Industrial Zone, Xi'an City, Shaanxi Province, China
Contact:0086 13585563621
Address:Suite 302, Block B2, Building #19, No. 528 Ruiqing Rd. Pudong, Shanghai 201201, China
Geen Chemical Technology Co., Ltd
Contact:86-769-21660847
Address:1408, Yingfeng Commercial Center, Nancheng District
Nanjing Raise Pharmatech Co., Ltd
website:http://www.raisechem.com
Contact:+86-25-58649566
Address:B381,No.606,Ningliu Road,Jiangbei New Area,Nanjing,Jiangsu Province,China
Contact:0086 13585563621
Address:Suite 302, Block B2, Building #19, No. 528 Ruiqing Rd. Pudong, Shanghai 201201, China
Doi:10.1039/c3cc44215b
(2013)Doi:10.1002/chem.201800381
(2018)Doi:10.1021/jo00956a001
(1973)Doi:10.1016/j.tetlet.2011.05.114
(2011)Doi:10.1016/j.bmc.2008.08.006
(2008)Doi:10.1016/S0040-4039(01)01766-X
(2001)
