39631-33-9

Usage

Uses

Used in Pharmaceutical Research:
5-(4-BROMO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL is used as a building block for the synthesis of various organic compounds, particularly in the development of new pharmaceutical agents. Its unique structure and properties make it a promising candidate for the creation of novel therapeutic agents.
Used in Medicinal Chemistry:
5-(4-BROMO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL is used as a valuable tool in medicinal chemistry for the exploration of its potential biological activities. Its presence in various chemical reactions and its ability to interact with other molecules make it a useful compound for studying and understanding the mechanisms of drug action.
Used in Drug Discovery:
5-(4-BROMO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL is used in drug discovery to identify and develop new therapeutic agents with potential applications in treating various diseases and conditions. Its unique structure and properties make it a valuable asset in the search for new drugs with improved efficacy and safety profiles.
Used in Chemistry and Biochemistry Research:
5-(4-BROMO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL is used as a research tool in the fields of chemistry and biochemistry to study its properties and interactions with other compounds. This knowledge can contribute to the development of new synthetic methods, understanding of chemical reactions, and the discovery of new applications for 5-(4-BROMO-PHENYL)-4H-[1,2,4]TRIAZOLE-3-THIOL.

InChI:InChI=1/C8H6BrN3S/c9-6-3-1-5(2-4-6)7-10-8(13)12-11-7/h1-4H,(H2,10,11,12,13)

Upstream product

• 5933-32-4 4-bromobenzoic acid hydrazide 
• 39631-30-6 2-(4-bromobenzoyl)hydrazinecarbothioamide 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 586-76-5 4-Bromobenzoic acid 
• 79-19-6 thiosemicarbazide 
• 586-75-4 4-chlorobenzoyl chloride 

Downstream Products

• 1190602-21-1 C₂₄H₂₀Br₂N₈S₂ 
• 1276032-83-7 5-p-bromophenyl-3-(β-D-glucopyranosylthio)-1,2,4-triazole 
• 1276032-73-5 5-p-bromophenyl-3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylthio)-1,2,4-triazole 
• 1620200-78-3 diethyl (3-((5-(4-bromophenyl)-1H-1,2,4-triazol-3-yl)thio)propyl)phosphonate 
• 1383783-65-0 4-(2-{[5-(4-bromophenyl)-4H-1,2,4-triazol-3-yl]thio}ethoxy)benzaldehyde 
• 106014-00-0 2,6-Bis-(4-bromo-phenyl)-thiazolo[3,2-b][1,2,4]triazole 
• 106014-01-1 2-(4-Bromo-phenyl)-6-(4-chloro-phenyl)-thiazolo[3,2-b][1,2,4]triazole 
• 106020-12-6 2-(p-Bromophenyl)-5-(p-tolyl)thiazolo<3,2-b>-s-triazole 
• 106013-98-3 1-(4-Bromo-phenyl)-2-[5-(4-bromo-phenyl)-4H-[1,2,4]triazol-3-ylsulfanyl]-ethanone; hydrobromide 
• 106013-97-2 3-(p-Bromophenyl)-5-(p-methylphenacylthio)-s-triazole hydrobromide 

Relevant academic research and scientific papers

Dammarane sapogenin derivative and preparation method and application thereof

The invention belongs to the technical field of medicines, and relates to a dammarane sapogenin derivative and a preparation method and application thereof. A series of dammarane sapogenin derivativesare obtained by combining dammarane sapogenins from plants with different groups. Anticancer activity evaluation and anticancer activity mechanism research are carried out on the derivative, and results show that the prepared dammarane sapogenin derivative has a remarkable anticancer effect, has no toxic effect on normal cells and can be used for preparing drugs for treating cancers.

An efficient nonconventional glycerol-based solid acid catalyzed synthesis and biological evaluation of phosphonate conjugates of 1,2,4-triazole thiones

A series of diethyl (3-((5-aryl-1H-1,2,4-triazol-3-yl)thio)propyl)phos-phonates (7a-t) has been synthesized in excellent yields by coupling diethyl (3-bromopropyl)phosphonate and 5-aryl-1H- 1,2,4-triazol-3-thiones employing an efficient, green and nonconventional heterogeneous SO3Hcarbon catalyst derived from glycerol. In addition, a facile and green approach for the esterification of carboxylic acids by utilizing glycerol-based solid acid catalyst has been reported. Structures of the synthesized compounds were characterized by IR, NMR and HRMS studies. These triazole derivatives were screened for their in vitro cytotoxicity using the standard MTT (3-(4,5-dimethylthiazol-2- yl)-2,5-diphenyltetra-zolium bromide) assay against a panel of five different human cancer cell lines (HeLa: Cervix, A549: Lung, A375: Skin, MDA-MB-231: Breast and T98G: Brain). The antimicrobial activities of the synthesized compounds were investigated against four bacterial strains: Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and three fungal strains: Aspergillus Niger, Aspergillus terreus, Aspergillus fumigatus. Preliminary results indicate that the compound 7f displayed maximum anticancer activity and the compounds 7d, 7e, 7f, 7m and 7q exhibited moderate antibacterial activity. The compounds 7g, 7h, 7o and 7p showed good antifungal activity with high inhibition zone diameter compared to the standard drug.

Magnetically Recyclable Nano-Fe 2O 3-Catalyzed Chemoselective Synthesis and Antioxidant Activity of Diethyl (3-((5-Aryl-1 H-1,2,4-triazol-3-yl)thio)propyl) phosphonates

An efficient, green, and chemoselective S-alkylation of 5-aryl-1H-1,2,4-triazole-3-thiones with diethyl (3-bromopropyl)phosphonate in water, catalyzed by nano-Fe2O3 under ligand-and base-free conditions, is reported. Clean reaction, less expensive catalyst, excellent yields, and easy workup are the advantages of the present method. The catalyst can be easily collected by a magnet and recycled without significant loss in catalytic activity. The newly synthesized compounds were screened for their antioxidant property by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay. The majority of the compounds exhibited good antioxidant activity.

Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring

Novel thiazolidinedione derivatives were synthesized by incorporating pharmacologically significant heterocycles viz, substituted thiazole, triazole, and oxadiazole moieties linked to the central phenyl ring via heteroatomlinkage with one/two carbon spacer as the structural analogs of Pioglitazone by employing multistep synthetic protocols. Structures of all the newly synthesized intermediates and target molecules were established by analytical and spectral data. These newly synthesized compounds were screened for their invivo hypoglycemic and hypolipidemic activities in male wistar rats. Some of the synthesized compounds demonstrated good activity.

Synthesis and antibacterial activities of new S-glycosides bearing 1,2,4-triazole

Several new 5-aryl-3-(β-D-glucopyranosylthio)-1,2,4-triazoles have been synthesized. The structures of these new compounds were confirmed by 1H NMR, 13C NMR and elemental analyses.The antibacterial activities of the compounds were also evaluated.

Heterocyclic Systems Containing Bridgehead Nitrogen Atom: Part XLVIII - Syntheses of Thiazolo-s-triazoles and Thiazolo-s-triazoles

The reaction of 3-p-bromophenyl-5-mercapto-s-triazole (II) with α-halogenoketones in anhyd. ethanol gives ketones (IIIa-c) which undergo cyclization in the presence of PPA to furnish thiazolo-s-triazoles (IVa-c) and not the isomeric thiazolo