39634-42-9

Usage

Uses

Used in Organic Synthesis:
4-[(4-Trifluoromethyl)phenoxy]phenol is used as a building block in organic synthesis for the creation of a variety of chemical compounds. Its unique structure and functional groups enable it to participate in numerous chemical reactions, making it a valuable component in the synthesis of new molecules with potential applications in various fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-[(4-Trifluoromethyl)phenoxy]phenol is utilized as a key intermediate in the development of new drugs. Its trifluoromethyl group is particularly useful for enhancing the biological properties of drug molecules, such as improving their stability, solubility, and pharmacokinetic profiles. This modification can lead to the discovery of more effective and safer medications for the treatment of various diseases.
Used in Medicinal Chemistry:
4-[(4-Trifluoromethyl)phenoxy]phenol plays a significant role in medicinal chemistry, where it is employed for the modification of drug molecules. The introduction of the trifluoromethyl group can alter the physicochemical properties of a drug, potentially increasing its potency, selectivity, and bioavailability. This modification can be crucial in the optimization of drug candidates, leading to the development of more effective therapeutic agents.

InChI:InChI=1/C13H9F3O2/c14-13(15,16)9-1-5-11(6-2-9)18-12-7-3-10(17)4-8-12/h1-8,17H

Upstream product

• 402-44-8 4-Fluorobenzotrifluoride 
• 123-31-9 hydroquinone 
• 459-57-4 4-fluorobenzaldehyde 
• 100-66-3 methoxybenzene 
• 98-56-6 4-chlorobenzotrifluoride 
• 67525-36-4 1,4-bis[4-(trifluoromethyl)phenoxy]benzene 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 402-45-9 4-hydroxybenzotrifluoride 
• 90035-20-4 4-(4-Trifluoromethylphenoxy)benzaldehyde 
• 53451-89-1 4-methoxyphenoxy-4-trifluoromethylphenyl ether 

Downstream Products

• 59011-97-1 2-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-pentanoic acid 
• 59011-96-0 3-Methyl-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-butyric acid 
• 59011-95-9 2-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-butyric acid 
• 59011-98-2 2-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-hexanoic acid 
• 59011-99-3 2-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-octanoic acid 
• 70791-36-5 α-[4-(p-trifluoromethylphenoxy)-phenoxy]-propionic acid n-butoxyethyl ester 
• 59011-52-8 2-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-propionic acid 4-chloro-phenyl ester 
• 59011-59-5 2-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-propionic acid benzyl ester 
• 59011-45-9 2-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-thiopropionic acid S-ethyl ester 
• 59011-46-0 2-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-propionic acid allyl ester 
• 59011-47-1 2-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-propionic acid prop-2-ynyl ester 
• 72326-21-7 (E)-4-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-pent-2-enethioic acid S-ethyl ester 
• 59011-39-1 2-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-propionic acid pentyl ester 
• 59011-40-4 2-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-propionic acid 1,3-dimethyl-butyl ester 

Relevant academic research and scientific papers

Method for selectively preparing hydroquinone monoether compound or quinol compound (by machine translation)

The method comprises the following steps: taking an organic boric acid compound and a p-benzoquinone compound as a reaction raw material, under the action of a copper catalyst, selectively reacting to obtain a hydroquinone monoether compound or a quinol compound. Compared with the prior art, the method disclosed by the invention adopts a one-pot reaction, can selectively obtain two products through solvent control, is suitable for preparing various types of hydroquinone monoether compounds and quinol compounds, and has wide applicability. The substrate functional group is high in tolerance and wide in substrate range. The raw material and the catalyst are cheap and easily available, the reaction conditions are mild, the reaction solvent is green and environment-friendly, the post-treatment is simple, and the yield and purity of the product are high. The preparation method is convenient. The method is rapid and efficient, and has a good application prospect in drug molecule synthesis. (by machine translation)

Preparation method of pyriproxyfen compounds

The invention provides a compound shown in structural formula I as well as stereoisomer, solvate and salt of the compound. In the structural formula I, R1 is selected from fluorine, chlorine, a cyano group or perfluoro-substituted C1-C3 alkyl; R2 is selected from hydrogen or C1-C3 alkyl; each of R3 and R4 is independently selected from hydrogen, C1-C3 alkyl, fluorine, chlorine or perfluoro-substituted C1-C3 alkyl; X is selected from O, S or -CH2-. The invention further provides a preparation method of the compound and an application of the compound in killing of harmful insects, public health epidemic prevention, control of plant diseases and insect pests and animal health care.

Design, synthesis and insecticidal evaluation of aryloxy dihalopropene derivatives

Plutella xylostella (P. xylostella) is a highly migratory, cosmopolitan species and one of the most important pest of cruciferous crops worldwide. Pyridalyl as a novel class of insecticides has good efficacy against P. xylostella. On the basis of the commercial insecticide pyridalyl, a series of new aryloxy dihalopropene derivatives were designed and synthesized by using Intermediate Derivatization Methods. Their chemical structures were confirmed by 1H NMR, high-resolution mass spectrum (HRMS), and single-crystal X-ray diffraction analysis. The insecticidal activities of the new compounds against P. xylostella were evaluated. The results of bioassays indicated that most of the compounds showed moderate to high activities at the tested concentration, especially compounds 10e and 10g displayed more than 75% insecticidal activity against P. xylostella at 6.25 mg/L, while pyridalyl showed 50% insecticidal activity at the same concentration. The field trials result of the insecticidal activities showed that compound 10e as a 10% emulsifiable concentrate (EC) was effective in the control of P. xylostella at 75-150 g a.i./ha, and the mortality of P. xylostella for treatment with compound 10e at 75 g a.i./ha was equivalent to pyridalyl at 105 g a.i./ha.

Selective displacement of aryl fluorides with hydroquinone: Synthesis of 4-phenoxyphenols

The selective displacement of a variety of aryl fluorides with hydroquinone has been achieved to give substituted 4-phenoxyphenols 3. In some cases the addition of 18-crown-6 resulted in a significant rate enhancement, and the reactions could be carried out at lower temperature. One of these derivatives, 3a (X = Cl) was converted to 2-propyl-4-(4-chlorophenoxy)phenol 2a, a precursor to the PPARγ receptor agonist 1.

5-Aryl thiazolidine-2,4-diones as selective PPARγ agonists

A series of 5-aryl thiazolidine-2,4-diones containing 4-phenoxyphenyl side chains was designed, synthesized, and evaluated for PPAR agonist activities. One such compound 28 exhibited comparable levels of glucose correction to rosiglitazone in the db/db mouse type 2 diabetes animal model.

Process for the manufacture of diphenyl ethers

Hydroquinone mono-phenyl ethers, and their alkali metal salts of the formula STR1 in which one of the radicals R1 and R2 denotes trifluoromethyl and the other denotes hydrogen or halogen and R3 represents hydrogen or an alkali metal cation or ammonium cation are prepared by reacting hydroquinone bis-phenyl ethers (bisphenoxybenzenes) of the formula STR2 with hydroquinone derivatives of the formula STR3 in which Cat denotes an alkali metal cation or ammonium cation and R4 denotes an alkali metal cation or ammonium cation or a (C1 -C4)-alkyl group, in a polar aprotic solvent at temperatures from 120° to 280° C., and optionally, an alkyl group present in the R4 -position is split off by treatment with an acid.

Phenyl ethers

Diphenyl ethers of the formula SPC1 Wherein R1 represents hydrogen or halogen and R2 hydrogen or a monovalent cation, are intermediates for the manufacture of selective herbicides.