39640-15-8

Usage

Uses

Used in Pharmaceutical Industry:
Piberaline is used as an antidepressant medication for the treatment of major depressive disorder, anxiety disorders, and other psychiatric conditions. It is effective in managing mood and reducing depressive and anxiety symptoms due to its action on serotonin levels in the brain.
Used in Mental Health Care:
Piberaline is used as a therapeutic agent to alleviate symptoms of stress and promote relaxation, capitalizing on its calming effect on the central nervous system. This makes it a valuable tool in mental health care for individuals dealing with stress and anxiety-related issues.

InChI:InChI=1/C17H19N3O/c21-17(16-8-4-5-9-18-16)20-12-10-19(11-13-20)14-15-6-2-1-3-7-15/h1-9H,10-14H2

Upstream product

• 29745-44-6 pyridine-2-carbonyl chloride 
• 2759-28-6 1-phenylmethylpiperazine 
• 100-51-6 benzyl alcohol 
• 389628-28-8 tert-butyl 4-picolinoylpiperazine-1-carboxylate 
• 98-98-6 2-Picolinic acid 
• 109-09-1 2-chloropyridine 
• 201230-82-2 carbon monoxide 

Downstream Products

• 130564-66-8 (4-Benzyl-piperazin-1-yl)-pyridin-2-yl-methanethione 

Relevant academic research and scientific papers

Mechanochemical Nucleophilic Substitution of Alcohols via Isouronium Intermediates**

An expansion of the solvent-free synthetic toolbox is essential for advances in the sustainable chemical industry. Mechanochemical reactions offer a superior safety profile and reduced amount of waste compared to conventional solvent-based synthesis. Here

Biologically Active Compounds through Catalysis: Efficient Synthesis of N-(Heteroarylcarbonyl)-N′-(arylalkyl)piperazines

A practical route for the synthesis of new biologically active 5-HT 2A receptor antagonists has been developed. In only three catalytic steps, this class of central nervous system (CNS) active compounds can be synthesized efficiently with high diversity. As the initial step, an anti-Markovnikov addition of amines to styrenes provides an easy route to N-(arylalkyl)piperazines, which constitute the core structure of the active molecules. Here, base-catalyzed hydroamination reactions of styrenes with benzylated piperazine proceeded in high yield even at room temperature. After catalytic debenzylation, the free amines were successfully carbonylated with different aromatic and heteroaromatic halides and carbon monoxide to yield the desired compounds in good to excellent yields. The two key reactions, base-catalyzed hydroamination of styrenes and palladium-catalyzed aminocarbonylation of haloarenes/heterocycles, showed tolerance towards various functional groups, thereby demonstrating the potential to synthesize a wide variety of new derivatives of this promising class of pharmaceuticals.

Synthesis and structure-activity relationships of novel arylalkyl 4- benzyl piperazine derivatives as σ site selective ligands

Continuing our previous work that established that some chromones substitued by an aryl alkyl piperazino alkyl side chain are potent and selective sigma ligands and could be interesting in the treatment of psychosis, we synthesized 60 new compounds, replacing the chromone moiety by various cyclic systems. Many derivatives bind to the sigma sites in the nanomolar range and are generally selective in comparison with 5HT(1A) and the D2 receptors. One of the most potent ligands of these series, 1-(2- naphthyl methyl)-4-benzyl piperazine 29, has been studied in various pharmacological tests. Although it doesn't have potential in the treatment of psychosis, the results we obtained confirm the data which indicates that such derivatives could be interesting in the treatment of inflammatory diseases. (C) 2000 Editions scientifiques et medicales Elsevier SAS.