39640-15-8

Basic information

• Product Name: Piberaline
• Synonyms: PIBERALINE;EGYT 475;1-Benzyl-4-(2'-pyridinecarbonyl)piperazine;1-(Phenylmethyl)-4-(2-pyridinylcarbonyl)piperazine;1-Benzyl-4-picolinoylpiperazine
• CAS NO: 39640-15-8
• Molecular Formula: C₁₇H₁₉N₃O
• Molecular Weight: 281.35
• Mol File: 39640-15-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 97 °C
• Boiling Point: 446.6 °C at 760 mmHg
• Flash Point: 223.9 °C
• Appearance: /
• Density: 1.186g/cm³
• Vapor Pressure: 3.59E-08mmHg at 25°C
• Refractive Index: 1.612
• PKA: 6.24±0.10(Predicted)
• CAS DataBase Reference: Piberaline(CAS DataBase Reference)
• NIST Chemistry Reference: Piberaline(39640-15-8)
• EPA Substance Registry System: Piberaline(39640-15-8)

Safety Data

• Hazardous Substances Data: 39640-15-8(Hazardous Substances Data)

Usage

General Description

Piberaline is a chemical compound that acts as a selective serotonin reuptake inhibitor (SSRI) and serotonin receptor antagonist. It is commonly used as an antidepressant medication to treat major depressive disorder, anxiety disorders, and other psychiatric conditions. Piberaline works by increasing the levels of serotonin in the brain, which helps to improve mood and reduce symptoms of depression and anxiety. It is also thought to have a calming effect on the central nervous system, making it useful in managing stress and promoting relaxation. However, like other SSRIs, Piberaline may have potential side effects such as nausea, dry mouth, headache, and sexual dysfunction, and should be used under the supervision of a qualified healthcare professional.

InChI:InChI=1/C17H19N3O/c21-17(16-8-4-5-9-18-16)20-12-10-19(11-13-20)14-15-6-2-1-3-7-15/h1-9H,10-14H2

Upstream product

• 29745-44-6 pyridine-2-carbonyl chloride 
• 2759-28-6 1-phenylmethylpiperazine 
• 109-09-1 2-chloropyridine 
• 201230-82-2 carbon monoxide 
• 100-51-6 benzyl alcohol 
• 389628-28-8 tert-butyl 4-picolinoylpiperazine-1-carboxylate 
• 98-98-6 2-Picolinic acid 

Downstream Products

• 130564-66-8 (4-Benzyl-piperazin-1-yl)-pyridin-2-yl-methanethione 

Relevant articles and documents

Mechanochemical Nucleophilic Substitution of Alcohols via Isouronium Intermediates**

An expansion of the solvent-free synthetic toolbox is essential for advances in the sustainable chemical industry. Mechanochemical reactions offer a superior safety profile and reduced amount of waste compared to conventional solvent-based synthesis. Here

Synthesis and structure-activity relationships of novel arylalkyl 4- benzyl piperazine derivatives as σ site selective ligands

Continuing our previous work that established that some chromones substitued by an aryl alkyl piperazino alkyl side chain are potent and selective sigma ligands and could be interesting in the treatment of psychosis, we synthesized 60 new compounds, replacing the chromone moiety by various cyclic systems. Many derivatives bind to the sigma sites in the nanomolar range and are generally selective in comparison with 5HT(1A) and the D2 receptors. One of the most potent ligands of these series, 1-(2- naphthyl methyl)-4-benzyl piperazine 29, has been studied in various pharmacological tests. Although it doesn't have potential in the treatment of psychosis, the results we obtained confirm the data which indicates that such derivatives could be interesting in the treatment of inflammatory diseases. (C) 2000 Editions scientifiques et medicales Elsevier SAS.