39640-70-5

Basic information

• Product Name: cis-3,4-piperidinediol(SALTDATA: HCl)
• Synonyms: cis-3,4-piperidinediol(SALTDATA: HCl)
• CAS NO: 39640-70-5
• Molecular Formula: C5H12ClNO2
• Molecular Weight: 153.61
• Mol File: 39640-70-5.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 233.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.214±0.06 g/cm3(Predicted)
• PKA: 14.40±0.40(Predicted)
• CAS DataBase Reference: cis-3,4-piperidinediol(SALTDATA: HCl)(CAS DataBase Reference)
• NIST Chemistry Reference: cis-3,4-piperidinediol(SALTDATA: HCl)(39640-70-5)
• EPA Substance Registry System: cis-3,4-piperidinediol(SALTDATA: HCl)(39640-70-5)

Safety Data

• Hazardous Substances Data: 39640-70-5(Hazardous Substances Data)

Upstream product

• 725715-12-8 3-(phenylmethyl)-7-oxa-3-azabicyclo[4.1.0]heptane 
• 161157-50-2 tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate 
• 1260588-08-6 (cis)-(rac)-3,4-dihydroxy-piperidine-1-carboxylic acid benzyl ester 
• 2876-13-3 N-benzylpyridinium chloride 
• 40240-12-8 1-benzyl-1,2,3,6-tetrahydropyridine 
• 694-05-3 1,2,3,6-tetrahydropyridine 
• 99784-36-8 (2S,3R)-2-(benzyloxy)-3-(formyloxy)-5-nitropentanal 
• 204992-85-8 p-methoxyphenyl 5-azido-5-deoxy-2,3-di-O-acetyl-α-D-arabinofuranoside 
• 177420-28-9 (3R,4R,5R)-3,4-Bis-benzyloxy-5-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 
• 177420-27-8 (3R,4R,5R)-3,4-di-O-benzyl-3,4,5-trihydroxypiperidine 
• 177567-99-6 1,2,3-tri-O-acetyl-5-azido-5-deoxy-D-arabinofuranose 
• 266688-38-4 methyl 2,3-di-O-acetyl-4-cyano-4-deoxy-D-threonate 
• 266688-39-5 5-amino-2,3-di-O-acetyl-4,5-dideoxy-D-threo-pentono-1,5-lactam 
• 266688-37-3 methyl 4-cyano-4-deoxy-D-threonate 

Downstream Products

• 951766-53-3 (3R,4S)-1-tert-butoxycarbonyl-3,4-dihydroxypiperidine 
• 1323208-28-1 benzyl (3R,4R)-3,4-diacetoxypiperidine-1-carboxylate 
• 1323207-94-8 benzyl (3R,4R)-4-acetoxy-3-[tri-O-acetyl-β-D-xylopyranosyl-(1->4)-di-O-acetyl-β-D-xylosyloxy]piperidine-1-carboxylate 

Relevant articles and documents

CHEMICAL COMPOUND OF ISOCITRATE DEHYDROGENASE INHIBITOR, AND APPLICATION THEREOF

Provided are a chemical compound of an isocitrate dehydrogenase inhibitor, and an application thereof, belonging to the field of medicinal chemistry; specifically provided is the chemical compound represented by formula I, or its isomer, pharmaceutically acceptable salt, crystal, solvate, or prodrug, as well as their preparation methods and pharmaceutical compositions containing said chemical compound, and an application of said chemical compound or composition. The chemical compound has very good ability to inhibit mutant IDH2 enzyme activity and to inhibit mutant IDH2 neoplastic cells, and may be used for preventing and/or treating a tumor characterized by the presence of mutant IDH2.

Amination of meso-bromophenyl(polyalkyl)porphyrins: Synthesis of porphyrins containing a hydroxypiperidine fragment

5,15-Bis(4-bromophenyl)-2,8,12,18-tetraethyl-3,7,13,17-tetramethylporphyrin and 5-(4-bromophenyl)-13,17-dibutyl-2,3,7,8,12,18-hexamethylporphyrin were synthesized, and their palladium-catalyzed amination with a number of cyclic secondary amines, including hydroxypiperidines, was studied [Pd(OAc) 2, ligand, THF or dioxane, t-BuONa, 80-100°C]. The reactions of the meso-bromophenylporphyrins with piperidine and morpholine gave the corresponding amination products in quantitative yield. The amination with hydroxypiperidines required excess amine (3 equiv per bromine atom) and excess base (6-8 equiv) and was accompanied by formation of hydrodebromination products; in the reactions with the bis(bromophenyl)derivative, mixed products resulting from amination at one phenyl group and reductive debromination at the other were also formed. The yields of the amination products varied from good {75-50percent in the reactions with 4-hydroxypiperidine and trans-3-hydroxy-4-[4-(2- fluorophenyl)piperazin-1-yl]piperidine} to moderate (20-50percent, 3-hydroxypiperidine) and poor [11-25percent, trans-3,4-dihydroxypiperidine and trans-3-hydroxy-4-(4-hydroxypiperidin-1-yl)piperidine].

Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds

The present invention relates to alkyne compounds of general formula I wherein the groups and radicals A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. Moreover the invention relates to pharmaceutical compositions containing at least one alkyne according to the invention. By virtue of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity and diabetes.