40240-12-8Relevant articles and documents
Trans-3-Hydroxy-4-morpholinopiperidine - The pH-triggered conformational switch with a double flip
Samoshin, Andrey V.,Joo, Hyun,Korneichuk, Andrei Ya,Veselov, Ivan S.,Grishina, Galina V.,Samoshin, Vyacheslav V.
, p. 1020 - 1024 (2013)
Derivatives of trans-3-hydroxy-4-aminopiperidine are suggested as potential pH-sensitive conformational switches able to perform two consecutive flips (or flip-flop) when basicity/acidity of solution changes. Such a double switch of conformation was detected by 1H NMR for a model compound - trans-3-hydroxy-4-morpholinopiperidine. A combination of hydrogen bonding and electrostatic/dipole-dipole interactions was suggested for rationalization. Computational studies provided additional insight into the complex intra- and intermolecular forces that determine the relative stabilities of conformers. In similar structures an incorporated trans-3-hydroxy-4-aminopiperidine moiety can serve as a conformational pH-trigger when equipped with substituents designed to perform certain geometry-dependent functions, for example, as cation chelators or as lipid tails.
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Princet, Bruno,Anselme, Gilles,Pornet, Jacques
, p. 34 - 40 (1999)
The 3,3-bis(trimethylsilyl)propene reacts with iminium ions (generated in situ from primary amines) by an aminomethylation-desilylation process and a subsequent cyclization, leading to N-alkyl-1,2,3,6-tetrahydropyridines as principal products. Tetrahydro-1,3-oxazines with a bis(trimethylsilyl)methyl group may also be observed. When primary amines with a tertiary group are used, the reaction leads only to ω-aminovinylsilanes, the steric hindrance inhibiting the progression of the reaction.
PRMT5 INHIBITORS
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, (2021/06/26)
The present invention provides a compound selected from: compounds A, B, C, D and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds disclosed herein, pharmaceutic
ENANTIOMERIC COMPOUNDS
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, (2020/05/07)
The present invention relates to enantiomeric compounds, their use in stereospecific reactions and to a method of preparing enantiomeric compounds.
Normal Alpha Olefin Synthesis Using Dehydroformylation or Dehydroxymethylation
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Paragraph 0127; 0128; 0129, (2019/09/06)
The present invention discloses processes for producing normal alpha olefins, such as 1-hexene, 1-octene, 1-decene, and 1-dodecene in a multistep synthesis scheme from another normal alpha olefin. Also disclosed are reactions for converting aldehydes, primary alcohols, and terminal vicinal diols into normal alpha olefins.