39644-71-8Relevant articles and documents
Synthesis of 1,5-benzodiazepine derivatives using p-toluenesulfonic acid as catalyst
Wang, Shasha,Hu, Lijuan,Cheng, Suyan,Wang, Lanzhi
, p. 419 - 424 (2015/01/30)
A series of substituted ethyl 4-oxo-4-phenylbut-2-enoates were prepared and reacted with substituted o-phenylenediamine, undergone Michael addition reactions and cyclodehydration to provide novel 4-phenyl-2,3-dihydro-1,5-benzodiazepine-2-carboxylate derivatives with excellent yields. The synthetic protocol fulfilled many green-chemical requirements by using simple catalyst p-toluenesulfonic acid as activator and ethanol as solvent at room temperature.