39652-85-2Relevant academic research and scientific papers
Synthesis and Structural Studies of Remirol
Yamaguchi, Seiji,Takai, Mayumi,Hanazome, Isao,Okada, Yuko,Kawase, Yoshiyuki
, p. 3603 - 3606 (1987)
One step cyclization of 2',4',6'-trihydroxyacetophenone with 1,4-dibromo-2-methyl-2-butene gave two 2-isopropenyl-2,3-dihydrobenzofuran-4,6-diols and a new 3-methyl-2,5-dihydro-1-benzoxepin-6,8-diol.The structure of natural remirol was confirmed by compar
Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen receptors α and β
Roelens, Frederik,Heldring, Nina,Dhooge, Willem,Bengtsson, Martin,Comhaire, Frank,Gustafsson, Jan-?ke,Treuter, Eckardt,De Keukeleire, Denis
, p. 7357 - 7365 (2007/10/03)
In search of therapeutic agents for estrogen-related pathologies, phytoestrogens are being extensively explored. In contrast to naringenin, 8-prenylnaringenin is a potent hop-derived estrogenic compound, highlighting the importance of the prenyl group for hormonal activity. We investigated the effects of substituting the prenyl group at C(8) with alkyl chains of varying lengths and branching patterns on estrogen receptor (ER) subtype ERα- and ERβ-binding affinities and transcriptional activities. In addition, features of the ligand-induced receptor conformations were explored using a set of specific ER-binding peptides. The new 8-alkylnaringenins were found to span an activity spectrum ranging from full agonism to partial agonism to antagonism. Most strikingly, 8-(2,2-dimethylpropyl)naringenin exhibited full agonist character on ERα, but pronounced antagonist character on ERβ. Knowledge on how ER-subtype-selective activities can be designed provides valuable information for future drug or tool compound discovery.
