39672-75-8

Usage

Uses

Used in Pharmaceutical Industry:
C₂₄H₃₀O₆ is used as an excipient for [application reason] in the pharmaceutical industry. It serves as a solvent, sweetening agent, and humectant in the formulation of various drugs, enhancing their stability, bioavailability, and overall effectiveness.
Used in Cosmetics Industry:
C₂₄H₃₀O₆ is used as a humectant for [application reason] in the cosmetics industry. It helps to retain moisture in the skin, providing hydration and improving the overall appearance and texture of the skin.
Used in Food Industry:
C₂₄H₃₀O₆ is used as a humectant and sweetening agent for [application reason] in the food industry. It helps to maintain the moisture content in various food products, improving their texture and shelf life.
Used in Oral Healthcare Products:
C₂₄H₃₀O₆ is used as a humectant and solvent for [application reason] in oral healthcare products, such as toothpaste and mouthwashes. It helps to maintain the moisture balance in the oral cavity, promoting overall oral health.
Used in Anticancer Applications (related to 9-Desfluoro-9(11)-epoxy Triamcinolone Acetonide):
C₂₄H₃₀O₆ is used as a solvent and excipient for [application reason] in the development of anticancer drugs, such as 9-Desfluoro-9(11)-epoxy Triamcinolone Acetonide. It aids in the formulation and delivery of these drugs, enhancing their efficacy and bioavailability.
Used in Drug Delivery Systems:
C₂₄H₃₀O₆ is used as a component in the development of drug delivery systems for [application reason] in various industries. Its properties make it suitable for encapsulation and controlled release of active pharmaceutical ingredients, improving their therapeutic outcomes.

Upstream product

• 117048-56-3 17-acetyl-10,13-dimethyl-6,7,8,10,12,13,14,15-octahydrocyclopenta[a]phenathren-3 
• 37413-91-5 2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate 
• 67-64-1 acetone 
• 5541-37-7 (4aS,6aS,6bS,9aR)-6b-(2-Hydroxy-acetyl)-4a,6a,8,8-tetramethyl-4a,6,6a,6b,9a,10,10a,10b,11,12-decahydro-7,9-dioxa-pentaleno[2,1-a]phenanthren-2-one 
• 39672-76-9 (10S,13S,16R,17S)-16,17-Dihydroxy-17-(2-hydroxy-acetyl)-10,13-dimethyl-6,7,8,10,12,13,14,15,16,17-decahydro-cyclopenta[a]phenanthren-3-one 

Relevant academic research and scientific papers

Preparation method of triamcinolone acetonide

The preparation method comprises the following steps: an oxidation reaction, a hydrolysis reaction, an epoxy reaction and a fluorine-containing reaction. After formic acid is added to the organic solvent acetone, a certain amount of the oxidant potassium permanganate is added after formic acid is added, and after the thin layer is analyzed to no raw material, a certain amount of the reducing liquid is added into the reactor, and after the reaction is complete, a certain amount of water is added, and after the reaction is complete 55 - 65min, the oxide is obtained by suction filtration. The method is mild in reaction condition, easy to control and small in auxiliary material toxicity. The preparation method adopts the transformation of 9, 11-position, 16,17-position and 21-position, can obtain triamcinolone, adopts the company existing products as starting materials, is short in route, easily available in raw materials, free of auxiliary materials with strong toxicity, high in yield and low in cost.

Preparation method of triamcinolone acetonide

The invention provides a brand new synthesis route for preparation of triamcinolone acetonide; adopted raw materials are cheaper and are easy to obtain, reactive raw materials are hydroxylated and then protection is performed, five-membered ring double bonds are subjected to selective oxidation, a protection group is removed, di-hydroxyl after oxidization is protected, and six-membered ring doublebonds are subjected to epoxidation and then are subjected to ring-opening fluorination to obtain the triamcinolone acetonide product. The reaction process is easy to operate, the yield of each step is relatively high, and the purity of the obtained product is higher, the formation of by-products is effectively avoided, the production cost is reduced and industrialized production is facilitated.

Triamcinolone acetonide acetate preparation method

The invention provides a full-novel synthesizing route for preparing triamcinolone acetonide acetate. According to the full-novel synthetic route, utilized raw materials have lower cost and more easiness in obtaining. The synthetic route comprises the steps of hydroxylating reaction raw materials and protecting, then selectively oxidizing five-membered ring double bonds, removing a protecting group, then protecting oxidized di-hydroxyl, then epoxidizing six-membered ring double bonds, performing open-ring fluorination and esterfying hydroxyl to obtain a triamcinolone acetonide product. A reaction process has easiness in operation, yields of all the steps are higher, obtained products have higher purities, byproduct generation is effectively avoided, production cost is reduced, and industrial production is facilitated.