396725-94-3

Basic information

• Product Name: 1H-Benzimidazole-1-carboxylic acid, 5-bromo-2,3-dihydro-2-oxo-3-(phenylmethyl)-, 1,1-dimethylethyl ester
• CAS NO: 396725-94-3
• Molecular Formula: C19H19BrN2O3
• Molecular Weight: 403.275
• Mol File: 396725-94-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazole-1-carboxylic acid, 5-bromo-2,3-dihydro-2-oxo-3-(phenylmethyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole-1-carboxylic acid, 5-bromo-2,3-dihydro-2-oxo-3-(phenylmethyl)-, 1,1-dimethylethyl ester(396725-94-3)
• EPA Substance Registry System: 1H-Benzimidazole-1-carboxylic acid, 5-bromo-2,3-dihydro-2-oxo-3-(phenylmethyl)-, 1,1-dimethylethyl ester(396725-94-3)

Safety Data

• Hazardous Substances Data: 396725-94-3(Hazardous Substances Data)

Upstream product

• 1026735-66-9 5-Bromo-2-oxo-benzoimidazole-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 161468-52-6 ethyl 6-bromo-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate 
• 41120-23-4 ethyl 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate 
• 615-16-7 1,3-dihydro-2H-benzimidazol-2-one 
• 100-39-0 benzyl bromide 
• 161468-56-0 5-Bromo-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid 1,1-dimethylethyl ester 

Downstream Products

• 305790-50-5 1-Benzyl-6-(3-nitro-phenyl)-1,3-dihydro-benzoimidazol-2-one 
• 305790-49-2 1-benzyl-6-(3-chloro-phenyl)-1,3-dihydro-benzoimidazol-2-one 
• 161469-06-3 1-Benzyl-6-bromo-1,3-dihydro-benzoimidazole-2-one 

Relevant articles and documents

Synthesis and progesterone receptor antagonist activities of 6-aryl benzimidazolones and benzothiazolones

Novel 6-aryl benzimidazolones and benzothiazolones were prepared and examined as bioisosteres of the recently reported 6-aryl dihydroquinolines (1) for progesterone receptor (PR) antagonist activities. PR antagonist activities increased when compounds 9c-f possessed a more lipophilic group at position-1 and pendent aryl moiety para to NH moiety. Furthermore, conversion of carbonyl moiety of 9e,f to the thio-carbonyl led to benzoimidazolethiones 15a,b with significantly improved potency and binding affinity.