396726-00-4

Basic information

• Product Name: 2H-Benzimidazol-2-one, 5-(3-chlorophenyl)-1,3-dihydro-1-(phenylmethyl)-
• CAS NO: 396726-00-4
• Molecular Formula: C20H15ClN2O
• Molecular Weight: 334.805
• Mol File: 396726-00-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2H-Benzimidazol-2-one, 5-(3-chlorophenyl)-1,3-dihydro-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Benzimidazol-2-one, 5-(3-chlorophenyl)-1,3-dihydro-1-(phenylmethyl)-(396726-00-4)
• EPA Substance Registry System: 2H-Benzimidazol-2-one, 5-(3-chlorophenyl)-1,3-dihydro-1-(phenylmethyl)-(396726-00-4)

Safety Data

• Hazardous Substances Data: 396726-00-4(Hazardous Substances Data)

Upstream product

• 161468-78-6 3-Benzyl-6-bromo-2-oxo-2,3-dihydro-benzoimidazole-1-carboxylic acid ethyl ester 
• 161468-52-6 ethyl 6-bromo-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate 
• 100-39-0 benzyl bromide 
• 63503-60-6 3-chlorophenylboronic acid 
• 30770-12-8 1-benzyl-5-bromo-1,3-dihydro-benzoimidazol-2-one 

Relevant articles and documents

Synthesis and progesterone receptor antagonist activities of 6-aryl benzimidazolones and benzothiazolones

Novel 6-aryl benzimidazolones and benzothiazolones were prepared and examined as bioisosteres of the recently reported 6-aryl dihydroquinolines (1) for progesterone receptor (PR) antagonist activities. PR antagonist activities increased when compounds 9c-f possessed a more lipophilic group at position-1 and pendent aryl moiety para to NH moiety. Furthermore, conversion of carbonyl moiety of 9e,f to the thio-carbonyl led to benzoimidazolethiones 15a,b with significantly improved potency and binding affinity.