396730-17-9

Basic information

• Product Name: 3-Piperidinamine, N-(phenylmethyl)-
• CAS NO: 396730-17-9
• Molecular Formula: C12H18N2
• Molecular Weight: 190.288
• Mol File: 396730-17-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-Piperidinamine, N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Piperidinamine, N-(phenylmethyl)-(396730-17-9)
• EPA Substance Registry System: 3-Piperidinamine, N-(phenylmethyl)-(396730-17-9)

Safety Data

• Hazardous Substances Data: 396730-17-9(Hazardous Substances Data)

Upstream product

• 62595-74-8 3-bromopiperidine-2,6-dione 
• 100-46-9 benzylamine 
• 351432-17-2 3-(benzylamino)piperidine-2,6-dione 
• 55306-69-9 N-(3-piperidinyl)benzamide 

Downstream Products

• 396730-16-8 6-(phenylmethyl)-1,6-diazabicyclo[3,2,1]octan-7-one 

Relevant articles and documents

Synthesis method of trelagliptin intermediate

The invention belongs to the technical field of medicines, and particularly relates to a synthesis method of a trelagliptin intermediate (R)-3-aminopiperidine dihydrochloride. The synthesis method specifically comprises the following steps: 1) reducing carbonyl of a compound shown as a formula I in an organic solvent A by using a reducing agent to prepare a compound shown as a formula II; 2) splitting the compound shown in the formula II in an organic solvent B through a chiral reagent to prepare a compound shown in a formula III; and 3) removing the benzyl of the compound shown by the formula III by palladium on carbon to obtain the (R)-3-aminopiperidine dihydrochloride. The (R)-3-aminopiperidine dihydrochloride prepared by the method has high yield and purity, the HPLC purity is higher than 98.16%, and the optical purity is higher than 98.92%; and the synthesis method has the advantages of low price of initial raw materials, facilitation of reduction of industrial cost, short synthesis process route, mild reaction conditions and easy industrial realization.

Azabicyclic compounds, preparation thereof and use as medicines, in particular as antibacterial agents

The invention relates to new heterocyclic compounds of general formula (I), and their salts with a base or an acid: The invention also relates to a process for the preparation of these compounds as well as their use as medicaments, in particular as anti-bacterial agents.