39683-24-4

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 4-hydroxy-1-phenyl-pyrazole-3-carboxylate is used as an intermediate in the production of pharmaceutical drugs for its potential role in the synthesis of various drug candidates.
Used in Agrochemical Industry:
ethyl 4-hydroxy-1-phenyl-pyrazole-3-carboxylate is also utilized as an intermediate in the production of agrochemicals, where it may contribute to the development of new pesticides or other agricultural chemicals.
Used in Organic Synthesis:
Ethyl 4-hydroxy-1-phenyl-pyrazole-3-carboxylate is used as a building block in organic synthesis, enabling the creation of a wide range of organic compounds for various applications.
Used in Research and Development:
Due to its potential biological activity, ethyl 4-hydroxy-1-phenyl-pyrazole-3-carboxylate is employed in research and development for the exploration of new drugs and materials, contributing to scientific advancements in the respective fields.

InChI:InChI=1/C12H12N2O3/c1-2-17-12(16)11-10(15)8-14(13-11)9-6-4-3-5-7-9/h3-8,15H,2H2,1H3

Upstream product

• 252367-34-3 ethyl 4-chloro-2-(phenylhydrazono)-3-oxobutanoate 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 62-53-3 aniline 
• 10475-63-5 3-oxo-2-(phenylhydrazono)butyric acid ethyl ester 
• 252367-34-3 ethyl 4-chloro-2-(phenylhydrazono)-3-oxobutanoate 
• 39683-28-8 4-bromo-3-oxo-2-phenylhydrazono-butyric acid ethyl ester 

Relevant academic research and scientific papers

Structure-activity relationship studies for the development of inhibitors of murine adipose triglyceride lipase (ATGL)

High serum fatty acid (FA) levels are causally linked to the development of insulin resistance, which eventually progresses to type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) generalized in the term metabolic syndrome. Adipose triglyceride lipase (ATGL) is the initial enzyme in the hydrolysis of intracellular triacylglycerol (TG) stores, liberating fatty acids that are released from adipocytes into the circulation. Hence, ATGL-specific inhibitors have the potential to lower circulating FA concentrations, and counteract the development of insulin resistance and NAFLD. In this article, we report about structure–activity relationship (SAR) studies of small molecule inhibitors of murine ATGL which led to the development of Atglistatin. Atglistatin is a specific inhibitor of murine ATGL, which has proven useful for the validation of ATGL as a potential drug target.

Concise and efficient synthesis of 1H-pyrazoles: Reaction of [hydroxy(tosyloxy)iodo]benzene with ethyl 2,3-dioxobutanoate-2-arylhydrazones

Ethyl 2,3-dioxobutanoate-2-arylhydrazones 1 on treatment with [hydroxy(tosyloxy)iodo]benzene 2 at reflux temperature and followed by heating in the presence of N-ethyldiisopropylamine afforded the cyclized ethyl 1-aryl-4-hydroxy-1H-3-pyrazolecarboxylates 4 in good yield.

THE SYNTHESIS OF 1H-PYRAZOL-4-OLS FROM 2-(2-ALKYLIDENEHYDRAZINO)ACETIC ACIDS

A new general method for synthesizing 1H-pyrazol-4-ols by cyclizing 2-(2-alkylidenehydrazino)acetic acids with acetic anhydride in pyridine is reported.

SUBSTITUENT EFFECTS ON ACIDITIES AND TAUTOMERIC STRUCTURES OF 1-ARYL-3-ETHOXYCARBONYL-4-PYRAZOLONES AND THEIR 5-ARYLAZO DERVATIVES.

Two series of 1-aryl-3-ethoxycarbonyl-4-hydroxy-pyrazoles (1) and 1-(m-chlorophenyl)-3-ethoxycarbonyl-4-hydroxy-5-arylazopyrazoles (2) have been prepared and their acidities determined spectrophotometrically at 25 deg C and ionic strength of 0.1 in 60 vol