39685-31-9

Usage

Uses

Cefuracetime is an impurity of Cefuroxime, which is an antibacterial.

InChI:InChI=1/C17H17N3O8S/c1-8(21)28-6-9-7-29-16-12(15(23)20(16)13(9)17(24)25)18-14(22)11(19-26-2)10-4-3-5-27-10/h3-5,12,16H,6-7H2,1-2H3,(H,18,22)(H,24,25)/b19-11-/t12-,16-/m1/s1

Upstream product

• 97148-39-5 (Z)-2-methoxyimino-2-(furyl-2-yl)acetic acid ammonium salt 
• 17090-71-0 furan-2-yl-oxo-acetaldehyde 
• 67-62-9 O-Methylhydroxylamin 
• 957-68-6 7-Aminocephalosporanic acid 

Downstream Products

• 56271-94-4 (6R,7R)-7-[2-(2-furyl)-2-(methoxyimino)acetamido]-3-hydroxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 55268-75-2 Cefuroxime 

Relevant academic research and scientific papers

Method for synthesizing 3-decarbamoyl-acetyl-cefuroxime acid compound

The invention provides a method for synthesizing a 3-decarbamoyl-acetyl-cefuroxime acid compound. The method comprises the following steps: taking 2-(2-furyl)-2-oxo-acetaldehyde, 7-aminocephalosporanic acid and methoxyamine as raw materials; reacting the raw materials in a reaction solvent under the combined action of a first catalyst, an oxidizing agent and a second catalyst; and carrying out chromatography to obtain the 3-deaminobenzoyl acetyl cefuroxime acid compound. By using the method, the process steps are simple, the byproduct is mainly water, a large amount of other wastes do not exist, and the subsequent treatment cost and the environmental protection pressure are low.

Cefuroxime sodium compound prepared through advanced on-line process control technology and preparation thereof

The invention discloses a cefuroxime sodium compound prepared through an advanced on-line process control technology and a preparation thereof. The project of high-grade medical product refining crystallization technology research and development and industrialization receives national scientific and technological progress second prize in 2015. The advanced on-line process control technology belongs to the high-grade medical product refining crystallization technology. An X ray powder diffraction test on cefuroxime sodium shows that in the spectrum, main characteristic peaks represented by diffraction angle 2theta are as follows: 9.71 degrees, 14.18 degrees, 16.19 degrees, 21.10 degrees, 22.88 degrees, 25.16 degrees and 30.77 degrees. The compound has the characteristics of high purity, low impurity content, good fluidity and good stability. The preparation is a cefuroxime sodium injection.

A adopt the particle process crystal product molecular assembly and shape optimization technique of the new crystalline form of cefuroxime sodium compound and preparation (by machine translation)

The invention discloses a new crystalline form of cefuroxime sodium compound and its crystallization preparation method, the new crystalline form of the compound is sodium [...] particle process crystal product molecular assembly and shape optimization technique to prepare. The stability tests prove that the new crystalline form of compound has high purity, low impurity content, guide the low moisture, the good characteristic of stability. At the same time, the invention also discloses the preparation of cefuroxime sodium employing the above described head-injection for the preparation. (by machine translation)