39687-20-2

Upstream product

• 76-83-5 trityl chloride 
• 4304-12-5 (2R,3R,4S,5S,6R)-2-(benzyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 
• 86196-36-3 benzyl α-D-galactopyranoside 
• 100-51-6 benzyl alcohol 
• 66966-07-2 α/β‐L‐glucopyranosyl‐1,2,3,4,5‐pentaacetate 
• 10343-13-2 benzyl-2,3,4,6-tetra-O-acetyl-β-D-glucopyranoside 

Downstream Products

• 56775-63-4 benzyl 2,3,4-tri-O-acetyl-6-O-(triphenylmethyl)-β-D-glucopyranoside 
• 27851-27-0 benzyl 2,3,4-tri-O-benzoyl-6-O-trityl-β-D-glucopyranoside 
• 27851-28-1 (2R,3R,4S,5R,6R)-2,3,4,5-tetrakis(benzyloxy)-6-((trityloxy)methyl)tetrahydro-2H-pyran 
• 27851-29-2 benzyl 2,3,4-tri-O-benzyl-D-glucopyranoside 
• 566905-62-2 benzyl 2,3,4-tri-O-benzyl-6-O-imidazol-N-ylcarbonyl-β-D-glucopyranoside 
• 566905-73-5 benzyl 2,3,4-tri-O-benzyl-β-D-glucopyranoside 6-(hydrogen succinate) 
• 566905-64-4 benzyl 2,3,4-tri-O-benzyl-6-O-[N-(3,4-dibenzyloxyphenylethyl)aminocarbonyl]-β-D-glucopyranoside 
• 331233-69-3 (4aS,6R,7R,8R,8aR)-8-Benzyloxy-2,2-dimethyl-6-((2R,3R,4S,5R,6R)-3,4,5,6-tetrakis-benzyloxy-tetrahydro-pyran-2-ylmethoxy)-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol 
• 404378-60-5 (2S,3R,4S,5R,6R)-4-Benzyloxy-2-hydroxymethyl-6-((2R,3R,4S,5R,6R)-3,4,5,6-tetrakis-benzyloxy-tetrahydro-pyran-2-ylmethoxy)-tetrahydro-pyran-3,5-diol 
• 331233-71-7 (2R,3S,4S,5R,6R)-5-Acetoxy-4-benzyloxy-3-hydroxy-6-((2R,3R,4S,5R,6R)-3,4,5,6-tetrakis-benzyloxy-tetrahydro-pyran-2-ylmethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 331233-70-6 Acetic acid (2R,3R,4S,5R,6S)-4-benzyloxy-5-hydroxy-6-hydroxymethyl-2-((2R,3R,4S,5R,6R)-3,4,5,6-tetrakis-benzyloxy-tetrahydro-pyran-2-ylmethoxy)-tetrahydro-pyran-3-yl ester 
• 331233-68-2 Acetic acid (2R,3R,4S,5R,6S)-5-acetoxy-6-acetoxymethyl-4-benzyloxy-2-((2R,3R,4S,5R,6R)-3,4,5,6-tetrakis-benzyloxy-tetrahydro-pyran-2-ylmethoxy)-tetrahydro-pyran-3-yl ester 
• 331233-74-0 3-(3-azido-4-benzyloxy-6-hydroxymethyl-5-methoxy-tetrahydro-pyran-2-yloxy)-4-benzyloxy-5-hydroxy-6-(3,4,5,6-tetrakis-benzyloxy-tetrahydro-pyran-2-ylmethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 331233-72-8 5-acetoxy-3-(6-acetoxymethyl-3-azido-4-benzyloxy-5-methoxy-tetrahydro-pyran-2-yloxy)-4-benzyloxy-6-(3,4,5,6-tetrakis-benzyloxy-tetrahydro-pyran-2-ylmethoxy)-tetrahydro-pyran-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

AMPHETAMINE PRODRUGS

The present invention relates to amphetamine prodrugs which provide colonic release of amphetamine.

COMPOUNDS AND COMPOSITIONS FOR THE DETECTION AND TREATMENT OF ALZHEIMER'S DISEASE AND RELATED DISORDERS

One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyIoidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.

Synthesis of glycosyl derivatives as dopamine prodrugs: Interaction with glucose carrier GLUT-1

Glucosyl dopamine (DA) derivatives may represent a new class of DA prodrugs that would interact with glucose transporter GLUT-1, present in the blood-brain barrier, and generate DA in the brain. Therefore, compounds bearing the sugar moiety linked to eith

Synthesis of oligomeric assemblies of a platelet-binding key disaccharide in heparin and their biological activities

Heparin, highly sulfated glycosaminoglycan, binds to platelets. A key disaccharide unit in heparin was previously found to be responsible for the binding, and the frequency of the disaccharide unit was important for the binding potency. A newly developed method based on the reductive amination was effectively applied to prepare structurally defined oligomeric assemblies possessing multiple units of the key disaccharide. From their platelet-binding activities measured by the competitive binding assay, the enhancement of the activity was clearly observed with increasing number of the key disaccharide.

Syntheses of Benzyl 6-O-Sulfo-β-D-glucopyranoside Salts and Their 6S-Deuterated Analogues. Conformational Preferences of Their (Sulfonyloxy)methyl Group

The syntheses of benzyl 6-O-sulfo-β-D-glucopyranoside as the sodium (7), lithium (8), potassium (9), and calcium (10) salts in 30percent total yield from D-glucose are described.Sulfation of the 6-hydroxy compounds 5 and 17 involved quenching of the react

SYNTHESES OF A BRANCHED HEPTASACCHARIDE HAVING PHYTOALEXIN-ELICITOR ACTIVITY

Synteses are described of a D-glucose heptasaccharide, 1, corresponding to a glucan structure recognised by the soybean when infected by the fungus Phytophtora megasperma f. sp. glycinea and which stimulates the formation of phytoalexins.The synthetic strategy is based upon 1,2-trans-glycoside formation assisted by participating benzoate groups in the 2-position, with silver triflate as promoter and glycosyl bromides as donors for making the smaller fragments, and with methyl triflate as promoter with thioglycosides as donors for making the larger ones.Regioselective reductive openings of 4,6 benzylidene acetals play a key role in obtaining free 6-OH groups with benzyl protection at O-4.

Ditritylation of Methyl and Benzyl α-D-Gluco-, -Manno-, and -Galactopyranosides and Preparation of Their Partially Benzylated Derivatives

The ditritylation of methyl and benzyl α-D-gluco-, -manno-, and -galactopyranosides with trityl chloride in pyridine at 70 deg C proceeds in a regioselective manner to give the 2,6-ditrityl ethers of the glucosides, the 3,6-ones of the mannosides, and bot