39715-29-2

Upstream product

• 39716-48-8 ethyl 3-oxo-3,5,7,8-tetrahydropyrido[4,3-c]pyridazine-6(2H)-carboxylate 
• 39715-99-6 ethyl 3-chloro-7,8-dihydropyrido[4,3-c]pyridazine-6(5H)-carboxylate 

Downstream Products

• 1334203-49-4 5,6,7,8-tetrahydropyrido[4,3-c]pyridazin-3-amine 

Relevant academic research and scientific papers

5,6,7,8-Tetrahydropyrido[4,3- c ]pyridazine: A lead-oriented scaffold with two diversity points

An approach to the derivatives of 5,6,7,8-tetrahydropyrido[4,3-c] pyridazine, a lead-oriented scaffold with two diversity points, was developed. The method included five steps starting from the readily available 4-piperidone derivatives and allowed for the preparation of the target compounds in 32-35% overall yields. The key step of the sequence included one-pot solvent-free reaction of the corresponding 4-piperidone derivative, glyoxylic acid, and hydrazine.

3-Hydrazino-cycloalkyl[c]pyridazines

This invention provides aminopyridazine derivatives of formula I, SPC1 wherein R1 is amino, or an EQU1 group, wherein each of R3 and R4 is alkyl of 1 to 4 carbon atoms, or R3 and R4 together with the carbon atom to which they are bound, form a cycloalkylidene radical of 5 to 12 carbon atoms, R2 is hydrogen or methyl, A is a --(CH2)n -- group, Wherein n is 0 or an integer from 1 to 7, or an >N--CO--R5 group, Wherein R5 is alkyl or alkenyl of 1 to 16 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, 1-adamantyl, or a --(CH2)m --R6 group, Wherein m is 0 or an integer from 1 to 4, and R6 is phenyl; phenyl monosubstituted by fluorine, chlorine, bromine, alkyl or alkoxy of 1 to 4 carbon atoms, alkylmercapto of 1 to 4 carbon atoms, or phenyl; phenyl substituted by two or three substituents of the group chlorine, alkyl or alkoxy of 1 to 4 carbon atoms; diphenylmethyl, the phenyl rings of which may be monosubstituted by fluorine, chlorine, bromine, alkyl or alkoxy of 1 to 4 carbon atoms; or naphthyl, Or an --OR7 group, Wherein R7 is alkyl or alkenyl of 1 to 4 carbon atoms, or phenyl, phenylalkyl or phenylalkenyl which may be monosubstituted on the phenyl ring by chlorine, alkyl or alkoxy of 1 to 4 carbon atoms, and in which the alkylene or alkenylene chain is of 1 to 4 carbon atoms, And R8 and R9 are each hydrogen or alkyl of 1 to 4 carbon atoms, And acid addition salts thereof. The invention also provides processes for the production of said compounds. Said compounds and pharmaceutically acceptable acid addition salts thereof are useful as antihypertensive agents.