39715-99-6Relevant academic research and scientific papers
5,6,7,8-Tetrahydropyrido[4,3- c ]pyridazine: A lead-oriented scaffold with two diversity points
Borisov, Alexander V.,Voloshchuk, Volodymyr V.,Nechayev, Maxim A.,Grygorenko, Oleksandr O.
, p. 2413 - 2416 (2013/09/23)
An approach to the derivatives of 5,6,7,8-tetrahydropyrido[4,3-c] pyridazine, a lead-oriented scaffold with two diversity points, was developed. The method included five steps starting from the readily available 4-piperidone derivatives and allowed for the preparation of the target compounds in 32-35% overall yields. The key step of the sequence included one-pot solvent-free reaction of the corresponding 4-piperidone derivative, glyoxylic acid, and hydrazine.
